Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation

Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation

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http://www.wikidata.org/entity/Q24675835

Q24675835

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Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse The role of suppressors of cytokine signalling in human neoplasms Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy Activation of SOCS-3 by resistin Experimental endotoxemia induces adipose inflammation and insulin resistance in humans.Expression and functional significance of SOCS-1 and SOCS-3 in astrocytes SOCS1, a Negative Regulator of Cytokine Signals and TLR Responses, in Human Liver Diseases.Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT Satellite cells derived from obese humans with type 2 diabetes and differentiated into myocytes in vitro exhibit abnormal response to IL-6.Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice.The paradigm of IL-6: from basic science to medicine Activation of peroxisome proliferator-activated receptor-β/-δ (PPAR-β/-δ) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes.A new role for SOCS in insulin action. Suppressor of cytokine signaling.SOCS-1 deficiency does not prevent diet-induced insulin resistance.Regulation of TLR signaling and inflammation by SOCS family proteins.Periodontal bacterial DNA suppresses the immune response to mutans streptococcal glucosyltransferase A human model of inflammatory cardio-metabolic dysfunction; a double blind placebo-controlled crossover trial.Combined association analysis of interleukin 1-receptor antagonist (IL-1RN) variable number of tandem repeat (VNTR) and Haptoglobin 1/2 polymorphisms with type 2 diabetes mellitus risk.SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked?Frailty and safety: the example of diabetes.SOCS proteins in development and disease.SOCS proteins in regulation of receptor tyrosine kinase signaling.Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity.The C-terminus of CIS defines its interaction pattern.Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.Role of E3 ubiquitin ligases in insulin resistance.Identification of potential gene targets in systemic vasculitis using DNA microarray analysis.Effects of hepatitis C virus on suppressor of cytokine signaling mRNA levels: comparison between different genotypes and core protein sequence analysis.Autophagy inhibition enhances apoptosis induced by ginsenoside Rk1 in hepatocellular carcinoma cells.The Effect of Resistance Exercise on Inflammatory and Myogenic Markers in Patients with Chronic Kidney Disease.Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytes.Molecular mechanisms of insulin resistance in chronic kidney disease.Socs1 deficiency enhances hepatic insulin signaling.Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells.Regulation of hepatic insulin sensitivity by activating signal co-integrator-2.The dual function of hepatic SOCS3 in insulin resistance in vivo.

P2860

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P2860

Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation

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2001 nî lūn-bûn

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2001 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2001年の論文

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