HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.
about
Direct binding of human immunodeficiency virus type 1 Nef to the major histocompatibility complex class I (MHC-I) cytoplasmic tail disrupts MHC-I traffickingStructure--function relationships in HIV-1 Nef.The HIV-1 Nef protein as a target for antiretroviral therapy.Guanidine alkaloid analogs as inhibitors of HIV-1 Nef interactions with p53, actin, and p56lck.Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycinDown-regulation of cell surface CXCR4 by HIV-1Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways.HIV-1 Nef and T-cell activation: a history of contradictions.Nef-induced CD4 endocytosis in human immunodeficiency virus type 1 host cells: role of p56lck kinase.CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms.The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane.Effects of Release-Active Antibodies to CD4 Receptor on the Level of lck-Kinase in Cultured Mononuclear Cells from Human Peripheral Blood.TCR-induced T cell activation leads to simultaneous phosphorylation at Y505 and Y394 of p56(lck) residues.
P2860
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P2860
HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
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1999年学术文章
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1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
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1999年學術文章
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1999年學術文章
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name
HIV-1 Nef plays an essential r ...... n: dissociation of the CD4-p56
@nl
HIV-1 Nef plays an essential r ...... targeting of CD4 to lysosomes.
@en
type
label
HIV-1 Nef plays an essential r ...... n: dissociation of the CD4-p56
@nl
HIV-1 Nef plays an essential r ...... targeting of CD4 to lysosomes.
@en
prefLabel
HIV-1 Nef plays an essential r ...... n: dissociation of the CD4-p56
@nl
HIV-1 Nef plays an essential r ...... targeting of CD4 to lysosomes.
@en
P2093
P356
P1433
P1476
HIV-1 Nef plays an essential r ...... targeting of CD4 to lysosomes.
@en
P2093
P304
P356
10.1006/VIRO.1999.9642
P407
P577
1999-04-01T00:00:00Z