Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification.
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Regulation of the V-ATPase along the endocytic pathway occurs through reversible subunit association and membrane localizationRGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitroHCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and functionTargeted disruption of the Cl-/HCO3- exchanger Ae2 results in osteopetrosis in miceCharacterization of osteoclasts from patients harboring a G215R mutation in ClC-7 causing autosomal dominant osteopetrosis type IITGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and diseaseCryo-EM studies of the structure and dynamics of vacuolar-type ATPasesRegulation of osteoclasts by membrane-derived lipid mediatorsLoss of the V-ATPase B1 subunit isoform expressed in non-neuronal cells of the mouse olfactory epithelium impairs olfactory functionOptic nerve compression and retinal degeneration in Tcirg1 mutant mice lacking the vacuolar-type H-ATPase a3 subunitStructure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosisYeast V-ATPase complexes containing different isoforms of the 100-kDa a-subunit differ in coupling efficiency and in vivo dissociation.TMEM199 Deficiency Is a Disorder of Golgi Homeostasis Characterized by Elevated Aminotransferases, Alkaline Phosphatase, and Cholesterol and Abnormal GlycosylationThe amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding siteAcid phosphatases.Prevention of wear particle-induced osteolysis by a novel V-ATPase inhibitor saliphenylhalamide through inhibition of osteoclast bone resorptionV-ATPase subunit ATP6AP1 (Ac45) regulates osteoclast differentiation, extracellular acidification, lysosomal trafficking, and protease exocytosis in osteoclast-mediated bone resorptionDifferential localization of the vacuolar H+ pump with G subunit isoforms (G1 and G2) in mouse neuronsSynaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretionA proton pump ATPase with testis-specific E1-subunit isoform required for acrosome acidificationDissociation of bone resorption and bone formation in adult mice with a non-functional V-ATPase in osteoclasts leads to increased bone strengthThe proton translocation domain of cellular vacuolar ATPase provides a target for the treatment of influenza A virus infections.Properties of three isoforms of the 116-kDa subunit of vacuolar H+-ATPase from a single vertebrate species. Cloning, gene expression and protein characterization of functionally distinct isoforms in Gallus gallus.Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiationA deletion mutation in bovine SLC4A2 is associated with osteopetrosis in Red Angus cattle.Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption--implications for osteoclast qualityPA1b inhibitor binding to subunits c and e of the vacuolar ATPase reveals its insecticidal mechanismScreening of protein kinase inhibitors identifies PKC inhibitors as inhibitors of osteoclastic acid secretion and bone resorption.Activity-independent targeting of mTOR to lysosomes in primary osteoclastsA new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth rootsOsteopetrosis with micro-lacunar resorption because of defective integrin organizationAlendronate improves QOL of postmenopausal women with osteoporosis.The silencing of cathepsin K used in gene therapy for periodontal disease reveals the role of cathepsin K in chronic infection and inflammation.Versatile roles of V-ATPases accessory subunit Ac45 in osteoclast formation and functionRescue of ATPa3-deficient murine malignant osteopetrosis by hematopoietic stem cell transplantation in utero.Src inhibitors in the treatment of metastatic bone disease: rationale and clinical dataCalcium and bone disease.RANKL up-regulates brain-type creatine kinase via poly(ADP-ribose) polymerase-1 during osteoclastogenesis.Identification of a novel mutation in the coding region of the grey-lethal gene OSTM1 in human malignant infantile osteopetrosis.Seventeen a-subunit isoforms of paramecium V-ATPase provide high specialization in localization and function.
P2860
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P2860
Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Atp6i-deficient mice exhibit s ...... d extracellular acidification.
@en
Atp6i-deficient mice exhibit s ...... d extracellular acidification.
@nl
type
label
Atp6i-deficient mice exhibit s ...... d extracellular acidification.
@en
Atp6i-deficient mice exhibit s ...... d extracellular acidification.
@nl
prefLabel
Atp6i-deficient mice exhibit s ...... d extracellular acidification.
@en
Atp6i-deficient mice exhibit s ...... d extracellular acidification.
@nl
P2093
P356
P1433
P1476
Atp6i-deficient mice exhibit s ...... d extracellular acidification.
@en
P2093
P2888
P304
P356
10.1038/70563
P407
P577
1999-12-01T00:00:00Z