Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis.
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Structure- and substrate-based inhibitor design for Clostridium botulinum neurotoxin serotype ASNAP-25 Substrate Peptide (Residues 180-183) Binds to but Bypasses Cleavage by Catalytically Active Clostridium botulinum Neurotoxin EA Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic α-Exosite Binding RegionProteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavageSequencing the botulinum neurotoxin gene and related genes in Clostridium botulinum type E strains reveals orfx3 and a novel type E neurotoxin subtypeTetanus and botulinum neurotoxins: mechanism of action and therapeutic uses.High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitorsDrug Insight: biological effects of botulinum toxin A in the lower urinary tract.Comparison of the catalytic properties of the botulinum neurotoxin subtypes A1 and A5.Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1.Botulinum neurotoxin structure, engineering, and novel cellular trafficking and targeting.Role of the SNARE protein SNAP23 on cAMP-stimulated renin release in mouse juxtaglomerular cellsPaclitaxel is an inhibitor and its boron dipyrromethene derivative is a fluorescent recognition agent for botulinum neurotoxin subtype A.Crystal structure of botulinum neurotoxin type G light chain: serotype divergence in substrate recognition.SNAP-23 functions in docking/fusion of granules at low Ca2+.Receptor and substrate interactions of clostridial neurotoxins.Using fluorescent sensors to detect botulinum neurotoxin activity in vitro and in living cells.Clostridial neurotoxins: mechanism of SNARE cleavage and outlook on potential substrate specificity reengineering.The blockade of the neurotransmitter release apparatus by botulinum neurotoxins.Bioluminescence assay for the highly sensitive detection of botulinum neurotoxin A activity.Substrate recognition mechanism of VAMP/synaptobrevin-cleaving clostridial neurotoxins.Substrate recognition of VAMP-2 by botulinum neurotoxin B and tetanus neurotoxin.Glycine insertion at protease cleavage site of SNAP25 resists cleavage but enhances affinity for botulinum neurotoxin serotype A.Antimicrobial Peptides: New Recognition Molecules for Detecting Botulinum Toxins.Optimization of peptide substrates for botulinum neurotoxin E improves detection sensitivity in the Endopep-MS assay.Detection and quantification of botulinum neurotoxin type a by a novel rapid in vitro fluorimetric assay.The Inhibitory Effect of Botulinum Toxin Type A on Rat Pyloric Smooth Muscle Contractile Response to Substance P In Vitro.A Presynaptic Group III mGluR Recruits Gβγ/SNARE Interactions to Inhibit Synaptic Transmission by Cone Photoreceptors in the Vertebrate Retina.Tandem fluorescent proteins as enhanced FRET-based substrates for botulinum neurotoxin activity.A high-affinity competitive inhibitor of type A botulinum neurotoxin protease activity.Design and synthesis of substrate-based inhibitors of botulinum neurotoxin type B metalloprotease.Biologically active novel conformational state of botulinum, the most poisonous poison.Substrate recognition strategy for botulinum neurotoxin serotype A.Effects of transgenic expression of botulinum toxins in Drosophila.Distinct protein domains are responsible for the interaction of Hrs-2 with SNAP-25. The role of Hrs-2 in 7 S complex formation.Comparison of fluorigenic peptide substrates PL50, SNAPTide, and BoTest A/E for BoNT/A detection and quantification: exosite binding confers high-assay sensitivity.Mechanism of substrate recognition by botulinum neurotoxin serotype A.Unique substrate recognition by botulinum neurotoxins serotypes A and E.Multiple Pocket Recognition of SNAP25 by Botulinum Neurotoxin Serotype EPhenotypic effect of botulinum toxin A onCaenorhabditis elegans
P2860
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P2860
Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis.
@en
Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis.
@nl
type
label
Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis.
@en
Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis.
@nl
prefLabel
Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis.
@en
Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis.
@nl
P2093
P2860
P1433
P1476
Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis.
@en
P2093
C Montecucco
M C Wilson
P Washbourne
R Pellizzari
P2860
P356
10.1016/S0014-5793(97)01328-8
P407
P577
1997-11-01T00:00:00Z