Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
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Stathmin is dispensable for tumor onset in miceHigh resolution melting for mutation scanning of TP53 exons 5-8Li-fraumeni syndromeModulation of the vitamin D3 response by cancer-associated mutant p53Mutant p53 disrupts mammary tissue architecture via the mevalonate pathwayMutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasionMitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activityTrim24 targets endogenous p53 for degradationDRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loopTAp63 prevents premature aging by promoting adult stem cell maintenanceContextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expressionp53 acetylation is crucial for its transcription-independent proapoptotic functionsMutant p53 attenuates the SMAD-dependent transforming growth factor beta1 (TGF-beta1) signaling pathway by repressing the expression of TGF-beta receptor type IIMutational hotspots in the TP53 gene and, possibly, other tumor suppressors evolve by positive selection.Mouse Models Recapitulating Human Adrenocortical Tumors: What Is Lacking?Mutant p53: One, No One, and One Hundred ThousandRegulation of Mutant p53 Protein ExpressionThe Contrived Mutant p53 Oncogene - Beyond Loss of FunctionsMutant p53: Multiple Mechanisms Define Biologic Activity in CancerLinks between mutant p53 and genomic instabilityTumor suppressor p53 and its gain-of-function mutants in cancerTumor suppressor p53 and its mutants in cancer metabolismSmoking, p53 mutation, and lung cancerThe role of tumor suppressor p53 in the antioxidant defense and metabolismThe rebel angel: mutant p53 as the driving oncogene in breast cancer.p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse modelGain of function of mutant p53: R282W on the peak?Emerging Non-Canonical Functions and Regulation by p53: p53 and StemnessGenetically engineered mouse models in oncology research and cancer medicineArsenic trioxide reactivates proteasome-dependent degradation of mutant p53 protein in cancer cells in part via enhanced expression of Pirh2 E3 ligasep73 as a pharmaceutical target for cancer therapySeparase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in micep53 ubiquitination: Mdm2 and beyondMutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers.Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancerMutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion.Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome
P2860
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P2860
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
@en
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
@nl
type
label
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
@en
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
@nl
prefLabel
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
@en
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
@nl
P2093
P1433
P1476
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.
@en
P2093
Adel K El-Naggar
Gene A Lang
Guillermina Lozano
John M Parant
Lisa C Caldwell
Louise C Strong
Tamara Terzian
Tomoo Iwakuma
V Ashutosh Rao
P304
P356
10.1016/J.CELL.2004.11.006
P407
P577
2004-12-01T00:00:00Z