Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery.

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Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections

P2860

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P2860

Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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2017年學術文章

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Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery.

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Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery.

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label

Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery.

@en

Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery.

@nl

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Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery.

@en

Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery.

@nl

P1154

2-s2.0-85034067100

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P1433

Chemical Communications

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Modular synthesis of thirty lead-like scaffolds suitable for CNS drug discovery.

@en

P2093

Joan Mayol-Llinàs

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William Farnaby

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P2860

Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?

Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery

A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool.

Scaffold diversity of exemplified medicinal chemistry space.

Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.

Fragment-based hit identification: thinking in 3D.

A unified lead-oriented synthesis of over fifty molecular scaffolds.

Lead-oriented synthesis: Investigation of organolithium-mediated routes to 3-D scaffolds and 3-D shape analysis of a virtual lead-like library.

The O-acylation of ketone enolates by allyl 1H-imidazole-1-carboxylate mediated with boron trifluoride etherate: a convenient procedure for the synthesis of substituted allyl enol carbonates.

Lead-oriented synthesis: a new opportunity for synthetic chemistry.

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12345-12348

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scholarly article

P356

10.1039/C7CC06078E

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English

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P478

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Adam Nelson

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28489015

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2017-11-03T00:00:00Z

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1092516567

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144576913

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29099137

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121527/