Genetic and pharmacological targeting of TPL-2 kinase ameliorates experimental colitis: a potential target for the treatment of Crohn's disease?

Genetic and pharmacological targeting of TPL-2 kinase ameliorates experimental colitis: a potential target for the treatment of Crohn's disease?

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http://www.wikidata.org/entity/Q52891216
Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice.Macrophages in multiple myeloma: emerging concepts and therapeutic implications.Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis.Pharmacological inhibition of TPL2/MAP3K8 blocks human cytotoxic T lymphocyte effector functions.Tumor progression locus 2 differentially regulates IFNγ and IL-17 production by effector CD4+ T cells in a T cell transfer model of colitisEP4 Receptor-Associated Protein in Macrophages Ameliorates Colitis and Colitis-Associated Tumorigenesis.Genetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury.Inhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4.Severe changes in colon epithelium in the Mecp2-null mouse model of Rett syndrome.Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier Function.Tpl2 promotes neutrophil trafficking, oxidative burst, and bacterial killing.Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis.A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion.Hydroxylase inhibition regulates inflammation-induced intestinal fibrosis through the suppression of ERK-mediated TGF-β1 signaling. [corrected].TPL2 is a key regulator of intestinal inflammation in C. difficile infection.
P2860

Genetic and pharmacological targeting of TPL-2 kinase ameliorates experimental colitis: a potential target for the treatment of Crohn's disease?

Item
http://www.wikidata.org/entity/Q52891216
description
2011 nî lūn-bûn
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2011年の論文
@ja
2011年学术文章
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2011年学术文章
@zh
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
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2011年學術文章
@zh-hant
name
Genetic and pharmacological ta ...... treatment of Crohn's disease?
@en
Genetic and pharmacological ta ...... treatment of Crohn's disease?
@nl
type
label
Genetic and pharmacological ta ...... treatment of Crohn's disease?
@en
Genetic and pharmacological ta ...... treatment of Crohn's disease?
@nl
prefLabel
Genetic and pharmacological ta ...... treatment of Crohn's disease?
@en
Genetic and pharmacological ta ...... treatment of Crohn's disease?
@nl
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P433
P478
P50
P577
P5875
P6179
P698
P921
P356
P1433
P1476
Genetic and pharmacological ta ...... treatment of Crohn's disease?
@en
P2093
P2860
P2888
P304
P31
P356
P433
P478
P50
P577
P5875
P6179
P698
P921