Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage.
about
MicroRNA biogenesis pathways in cancerThe disparate origins of ovarian cancers: pathogenesis and prevention strategies.Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumourPituitary blastoma: a pathognomonic feature of germ-line DICER1 mutationsSomatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumoursDICER1-pleuropulmonary blastoma familial tumor predisposition syndrome: a unique constellation of neoplastic conditions.Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences.Pleuropulmonary blastoma: a report on 350 central pathology-confirmed pleuropulmonary blastoma cases by the International Pleuropulmonary Blastoma Registry.Solid tumors of childhood display specific serum microRNA profiles.Germ-line and somatic DICER1 mutations in pineoblastoma.Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastomaExpanding the phenotype of mutations in DICER1: mosaic missense mutations in the RNase IIIb domain of DICER1 cause GLOW syndrome.Transfer RNA detection by small RNA deep sequencing and disease association with myelodysplastic syndromes.The many faces of Dicer: the complexity of the mechanisms regulating Dicer gene expression and enzyme activitiesIdentification of somatic and germ-line DICER1 mutations in pleuropulmonary blastoma, cystic nephroma and rhabdomyosarcoma tumors within a DICER1 syndrome pedigree.The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors.High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer.Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in DICER1 syndrome: a unique variant of the two-hit tumor suppression model.Identification of germline DICER1 mutations and loss of heterozygosity in familial Wilms tumour.DICER1 hotspot mutations in non-epithelial gonadal tumours.Interaction-based discovery of functionally important genes in cancers.Germ-line deletion in DICER1 revealed by a novel MLPA assay using synthetic oligonucleotides.Dicer knockdown inhibits endothelial cell tumor growth via microRNA 21a-3p targeting of Nox-4.Role of microRNAs in cancers of the female reproductive tract: insights from recent clinical and experimental discovery studies.Cancer genomics: why rare is valuable.The co-occurrence of an ovarian Sertoli-Leydig cell tumor with a thyroid carcinoma is highly suggestive of a DICER1 syndrome.Recurrent DICER1 hotspot mutations in endometrial tumours and their impact on microRNA biogenesis.Temozolomide resistance in glioblastoma occurs by miRNA-9-targeted PTCH1, independent of sonic hedgehog level.Recently characterized molecular events in uncommon gynaecological neoplasms and their clinical importance.Serum levels of mature microRNAs in DICER1-mutated pleuropulmonary blastoma.New roles for Dicer in the nucleolus and its relevance to cancerReply: Serum microRNA screening for DICER1-associated pleuropulmonary blastoma.Germ-line and somatic DICER1 mutations in a pleuropulmonary blastoma.High-sensitivity sequencing reveals multi-organ somatic mosaicism causing DICER1 syndrome.Biallelic DICER1 mutations occur in Wilms tumours.DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry.The role of MicroRNA molecules and MicroRNA-regulating machinery in the pathogenesis and progression of epithelial ovarian cancer.Pleuropulmonary Blastoma: Evolution of an Entity as an Entry into a Familial Tumor Predisposition Syndrome.Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells.Serum microRNA screening for DICER1-associated pleuropulmonary blastoma.
P2860
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P2860
Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh-hant
name
Cancer-associated somatic DICE ...... gh loss of 5p strand cleavage.
@en
Cancer-associated somatic DICE ...... gh loss of 5p strand cleavage.
@nl
type
label
Cancer-associated somatic DICE ...... gh loss of 5p strand cleavage.
@en
Cancer-associated somatic DICE ...... gh loss of 5p strand cleavage.
@nl
prefLabel
Cancer-associated somatic DICE ...... gh loss of 5p strand cleavage.
@en
Cancer-associated somatic DICE ...... gh loss of 5p strand cleavage.
@nl
P2093
P2860
P356
P1476
Cancer-associated somatic DICE ...... gh loss of 5p strand cleavage.
@en
P2093
A Heravi-Moussavi
C Salamanca
D G Huntsman
S Maines-Bandiera
P2860
P304
P356
10.1002/PATH.4135
P577
2013-02-01T00:00:00Z