Pancreatic tumours escape from translational control through 4E-BP1 loss. - Wikidata - wikimedia - TriplyDB

Pancreatic tumours escape from translational control through 4E-BP1 loss.

Pancreatic tumours escape from translational control through 4E-BP1 loss.

http://www.wikidata.org/entity/Q53255717

about

Resistance to mTOR kinase inhibitors in lymphoma cells lacking 4EBP1 PI3K and cancer: lessons, challenges and opportunities p70S6 kinase is a critical node that integrates HER-family and PI3 kinase signaling networks.Matrine reduces the proliferation of A549 cells via the p53/p21/PCNA/eIF4E signaling pathway.mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance.Eukaryotic Translation Initiation Factor 4E Is a Feed-Forward Translational Coactivator of Transforming Growth Factor β Early Protransforming Events in Breast Epithelial Cells.mTOR coordinates protein synthesis, mitochondrial activity and proliferation.4E-BP restrains eIF4E phosphorylation Essential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2α expression and activity in cancer.4EBP-Dependent Signaling Supports West Nile Virus Growth and Protein Expression.Anti-metastatic potential of somatostatin analog SOM230: Indirect pharmacological targeting of pancreatic cancer-associated fibroblasts.Differential Regulation of ZEB1 and EMT by MAPK-Interacting Protein Kinases (MNK) and eIF4E in Pancreatic Cancer.mTOR in health and in sickness.mTOR kinase inhibitor pp242 causes mitophagy terminated by apoptotic cell death in E1A-Ras transformed cells 4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice.Expression of eukaryotic initiation factor 4E and 4E binding protein 1 in colorectal carcinogenesis.Targeting protein synthesis in cancer cells Survival of pancreatic cancer cells lacking KRAS function.Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1.Implication of 4E-BP1 protein dephosphorylation and accumulation in pancreatic cancer cell death induced by combined gemcitabine and TRAIL.Dual PI3K/mTOR Inhibition in Colorectal Cancers with APC and PIK3CA Mutations.

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Pancreatic tumours escape from translational control through 4E-BP1 loss.

http://www.wikidata.org/entity/Q53255717

description

2013 nî lūn-bûn

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年學術文章

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2013年學術文章

@zh-hant

name

Pancreatic tumours escape from translational control through 4E-BP1 loss.

@en

Pancreatic tumours escape from translational control through 4E-BP1 loss.

@nl

type

label

Pancreatic tumours escape from translational control through 4E-BP1 loss.

@en

Pancreatic tumours escape from translational control through 4E-BP1 loss.

@nl

prefLabel

Pancreatic tumours escape from translational control through 4E-BP1 loss.

@en

Pancreatic tumours escape from translational control through 4E-BP1 loss.

@nl

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Pancreatic tumours escape from translational control through 4E-BP1 loss

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C Bousquet

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C Lasfargues

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D Müller

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R Anesia

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R Azar

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S El Khawand

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S Pyronnet

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P2860

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission

4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity

Regulation of translation initiation in eukaryotes: mechanisms and biological targets

4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications

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1367-1374

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10.1038/ONC.2013.100

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11

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Jerry Pelletier

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2013-04-08T00:00:00Z

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