Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.
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Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient miceHippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's diseaseDysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosisCaenorhabditis elegans as a model organism to study APP functionApomorphine treatment in Alzheimer mice promoting amyloid-β degradationReduction in CHT1-mediated choline uptake in primary neurons from presenilin-1 M146V mutant knock-in micePresenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive declineMassive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic modelEarly life nutrient restriction impairs blood-brain metabolic profile and neurobehavior predisposing to Alzheimer's disease with aging.Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta proteinIntracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin.HH domain of Alzheimer's disease Abeta provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neuronsAlzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP.Accumulation of intraneuronal Abeta correlates with ApoE4 genotypeThe nuclear inclusion a (NIa) protease of turnip mosaic virus (TuMV) cleaves amyloid-βCalcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease.Back to the future with phenotypic screeningImmune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's diseaseInteraction of intracellular beta amyloid peptide with chaperone proteins.Distinct temporal and anatomical distributions of amyloid-β and tau abnormalities following controlled cortical impact in transgenic miceUntangling Alzheimer's disease from fibrous lesions of neurofibrillary tangles and senile plaques.A unifying hypothesis of Alzheimer's disease. IV. Causation and sequence of events.Gene-environment interaction research and transgenic mouse models of Alzheimer's disease.Design of β-amyloid aggregation inhibitors from a predicted structural motif.Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis.Increased tau phosphorylation and impaired presynaptic function in hypertriglyceridemic ApoB-100 transgenic miceDeath and survival of neuronal cells exposed to Alzheimer's insults.Autophagy failure in Alzheimer's disease--locating the primary defect.Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease.When the DREAM is gone: from basic science to future prospectives in pain management and beyond.Inhibiting p38 mitogen-activated protein kinase attenuates cerebral ischemic injury in Swedish mutant amyloid precursor protein transgenic mice.Does my mouse have Alzheimer's disease?An Alzheimer's disease hypothesis based on transcriptional dysregulation.Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease.β-Amyloid and α-synuclein cooperate to block SNARE-dependent vesicle fusionAssociation of ApoE and LRP mRNA levels with dementia and AD neuropathology.Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degenerationCurcumin protects against intracellular amyloid toxicity in rat primary neurons.Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.
P2860
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P2860
Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Transgenic mice with Alzheimer ...... hout amyloid plaque formation.
@en
Transgenic mice with Alzheimer ...... hout amyloid plaque formation.
@nl
type
label
Transgenic mice with Alzheimer ...... hout amyloid plaque formation.
@en
Transgenic mice with Alzheimer ...... hout amyloid plaque formation.
@nl
prefLabel
Transgenic mice with Alzheimer ...... hout amyloid plaque formation.
@en
Transgenic mice with Alzheimer ...... hout amyloid plaque formation.
@nl
P2093
P356
P1433
P1476
Transgenic mice with Alzheimer ...... hout amyloid plaque formation.
@en
P2093
Shirotani K
P2888
P304
P356
10.1038/8438
P407
P577
1999-05-01T00:00:00Z