Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.
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The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Abeta generation in vivo.Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearanceMetals and amyloid-beta in Alzheimer's diseaseZinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluidIron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's diseaseFenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's diseaseWhy nutraceuticals do not prevent or treat Alzheimer's diseaseMining literature for a comprehensive pathway analysis: a case study for retrieval of homocysteine related genes for genetic and epigenetic studiesMulti-Target Directed Donepezil-Like Ligands for Alzheimer's DiseaseMetals and Neuronal Metal Binding Proteins Implicated in Alzheimer's DiseaseAlzheimer's Disease: Mechanism and Approach to Cell TherapyNanotechnology-based drug delivery systems for the treatment of Alzheimer's diseaseIron dysregulation in Huntington's diseaseCopper signaling in the mammalian nervous system: synaptic effectsStructure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasisIron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesMetallomic profiling and linkage map analysis of early Parkinson's disease: a new insight to aluminum marker for the possible diagnosisAmyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assembliesModulation of tau phosphorylation by environmental copper.Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways.Mechanisms of copper ion mediated Huntington's disease progressionBinding of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-beta peptide.Hydroxyl radical oxidation of guanosine 5'-triphosphate (GTP): requirement for a GTP-Cu(II) complex.HH domain of Alzheimer's disease Abeta provides structural basis for neuronal binding in PC12 and mouse cortical/hippocampal neuronsThe turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide: the emerging role in the pathogenesis of Alzheimer's disease.Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons.Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic miceThe Case for Abandoning Therapeutic Chelation of Copper Ions in Alzheimer's DiseaseAlzheimer's Aβ peptides with disease-associated N-terminal modifications: influence of isomerisation, truncation and mutation on Cu2+ coordination.Endogenous zinc in neurological diseases.A prochelator activated by hydrogen peroxide prevents metal-induced amyloid Beta aggregation.Selective neuronal vulnerability to oxidative stress in the brain.Alzheimer disease beta-amyloid activity mimics cholesterol oxidase.Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease.Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.Mysterious oligomerization of the amyloidogenic proteinsThe galvanization of beta-amyloid in Alzheimer's disease.Antioxidant therapy in Alzheimer's disease: theory and practice.Insights on antioxidant assays for biological samples based on the reduction of copper complexes-the importance of analytical conditions.
P2860
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P2860
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Cu(II) potentiation of alzheim ...... roduction and metal reduction.
@en
type
label
Cu(II) potentiation of alzheim ...... roduction and metal reduction.
@en
prefLabel
Cu(II) potentiation of alzheim ...... roduction and metal reduction.
@en
P2093
P50
P356
P1476
Cu(II) potentiation of alzheim ...... production and metal reduction
@en
P2093
C L Masters
C S Atwood
E F Bowden
G Multhaup
G R Hanson
K C Stokes
L E Goldstein
M A Hartshorn
P304
37111-37116
P356
10.1074/JBC.274.52.37111
P407
P577
1999-12-01T00:00:00Z