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Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease. Implications for the catalytic mechanismArchitecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayerMultiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factorProteases universally recognize beta strands in their active sitesConformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processingTargeting the chromosome partitioning protein ParA in tuberculosis drug discoveryStructural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical AntifungalsHoney bee dopamine and octopamine receptors linked to intracellular calcium signaling have a close phylogenetic and pharmacological relationship.Unique residues involved in activation of the multitasking protease/chaperone HtrA from Chlamydia trachomatis.Macrocycles mimic the extended peptide conformation recognized by aspartic, serine, cysteine and metallo proteases.Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists.Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure.A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production.Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylaseAbc1p is a multidrug efflux transporter that tips the balance in favor of innate azole resistance in Candida krusei.Variable Expression of GLIPR1 Correlates with Invasive Potential in Melanoma CellsChlamydia Serine Protease Inhibitor, targeting HtrA, as a New Treatment for Koala Chlamydia infection.Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanatesUpdate 1 of: Beta-strand mimetics.CtHtrA: the lynchpin of the chlamydial surface and a promising therapeutic target.Proteolytic activation of Chlamydia trachomatis HTRA is mediated by PDZ1 domain interactions with protease domain loops L3 and LC and beta strand β5.Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.A theory of mode of action of azolylalkylquinolines as DNA binding agents using automated flexible ligand docking.Anxiogenic and Stressor Effects of the Hypothalamic Neuropeptide RFRP-3 Are Overcome by the NPFFR Antagonist GJ14.Chemical Tools for Studying Lipid-Binding Class A G Protein-Coupled Receptors.In vivo seizure induction and affinity studies of domoic acid and isodomoic acids-D, -E and -F.Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from alpha-aminosuberic acid.Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.Site-directed mutagenesis and kinetic studies of the West Nile Virus NS3 protease identify key enzyme-substrate interactions.Pinnatoxins E, F and G target multiple nicotinic receptor subtypes.Beta-strand mimicking macrocyclic amino acids: templates for protease inhibitors with antiviral activity.Insight into pleiotropic drug resistance ATP-binding cassette pump drug transport through mutagenesis of Cdr1p transmembrane domains.Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.Determination of alpha-conotoxin binding modes on neuronal nicotinic acetylcholine receptors.[Fe₂L₃]⁴⁺ cylinders derived from bis(bidentate) 2-pyridyl-1,2,3-triazole "click" ligands: synthesis, structures and exploration of biological activity.Proteases and protease inhibitors in infectious diseases.Stability, Kinetic, and Mechanistic Investigation of 1,8-Self-Immolative Cinnamyl Ether Spacers for Controlled Release of Phenols and Generation of Resonance and Inductively Stabilized Methides.Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.Expression, purification, crystallization and preliminary crystallographic analysis of a thermostable lipase from Bacillus stearothermophilus P1
P50
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P50
description
researcher
@en
wetenschapper
@nl
name
J D Tyndall
@en
J D Tyndall
@nl
type
label
J D Tyndall
@en
J D Tyndall
@nl
prefLabel
J D Tyndall
@en
J D Tyndall
@nl
P106
P31
P496
0000-0003-0783-1635