In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides.
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Immune surveillance for ERAAP dysfunctionAntigenic peptide trimming by ER aminopeptidases--insights from structural studiesEndoplasmic reticulum aminopeptidase-1 functions regulate key aspects of the innate immune responseA Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen ProcessingRationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responsesFrom HLA-B27 to spondyloarthritis: a journey through the ER.Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulumThe internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.Pathways of antigen processing.Cutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzymeBalancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation.The specificity of trimming of MHC class I-presented peptides in the endoplasmic reticulum.Characterizing the specificity and cooperation of aminopeptidases in the cytosol and endoplasmic reticulum during MHC class I antigen presentationPlacental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1An overview of genetics of paediatric rheumatic diseases.A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition.Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells.Proteases in MHC class I presentation and cross-presentationThe carboxypeptidase ACE shapes the MHC class I peptide repertoireThymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells.ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responsesPortable flanking sequences modulate CTL epitope processing.Allele-Independent Turnover of Human Leukocyte Antigen (HLA) Class Ia MoleculesRole of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer.ERAP1 genetic variations associated with HLA-B27 interaction and disease severity of syndesmophytes formation in Taiwanese ankylosing spondylitis.Constitutive and inflammatory immunopeptidome of pancreatic β-cells.Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigensInteraction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing.Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selection.Comparative expression profiling for human endoplasmic reticulum-resident aminopeptidases 1 and 2 in normal kidney versus distinct renal cell carcinoma subtypesCoping with loss of perfection in the MHC class I peptide repertoire.ERAAP and tapasin independently edit the amino and carboxyl termini of MHC class I peptides.p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1Immunodominant, protective response to the parasite Toxoplasma gondii requires antigen processing in the endoplasmic reticulum.ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing.HLA-B27 misfolding and spondyloarthropathies.Don't mess with ERAAP!Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity.MHC class I assembly: out and about.
P2860
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P2860
In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
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2006年學術文章
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name
In the absence of aminopeptida ...... d highly immunogenic peptides.
@en
In the absence of aminopeptida ...... d highly immunogenic peptides.
@nl
type
label
In the absence of aminopeptida ...... d highly immunogenic peptides.
@en
In the absence of aminopeptida ...... d highly immunogenic peptides.
@nl
prefLabel
In the absence of aminopeptida ...... d highly immunogenic peptides.
@en
In the absence of aminopeptida ...... d highly immunogenic peptides.
@nl
P2093
P2860
P356
P1433
P1476
In the absence of aminopeptida ...... d highly immunogenic peptides.
@en
P2093
Edward James
Federico Gonzalez
Gianna Elena Hammer
Hector Nolla
Nilabh Shastri
P2860
P304
P356
10.1038/NI1409
P407
P577
2006-11-26T00:00:00Z