Mechanistic study of HCV polymerase inhibitors at individual steps of the polymerization reaction.
about
Virologic Tools for HCV Drug Resistance TestingActivity of a Potent Hepatitis C Virus Polymerase Inhibitor in the Chimpanzee ModelInhibition of Hepatitis C Virus (HCV) RNA Polymerase by DNA Aptamers: Mechanism of Inhibition of In Vitro RNA Synthesis and Effect on HCV-Infected Cells1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside InhibitorsHepatitis C Virus NS5B Polymerase Exhibits Distinct Nucleotide Requirements for Initiation and ElongationSlow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C VirusHelicase inhibitors as specifically targeted antiviral therapy for hepatitis CStructural and Functional Analysis of Hepatitis C Virus Strain JFH1 PolymeraseMechanism of Hepatitis C Virus RNA Polymerase Inhibition with DihydroxypyrimidinesAssembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complexInitiation of RNA synthesis by the hepatitis C virus RNA-dependent RNA polymerase is affected by the structure of the RNA template.Dynamics of hepatitis C virus (HCV) RNA-dependent RNA polymerase NS5B in complex with RNAmiR-122 does not modulate the elongation phase of hepatitis C virus RNA synthesis in isolated replicase complexes.Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B.Synthesis and SAR optimization of diketo acid pharmacophore for HCV NS5B polymerase inhibition.Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors.NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase.Thumb inhibitor binding eliminates functionally important dynamics in the hepatitis C virus RNA polymerase.Screening of hepatitis C NS5B polymerase inhibitors containing benzothiadiazine core: a steered molecular dynamics.In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor.Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors.
P2860
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P2860
Mechanistic study of HCV polymerase inhibitors at individual steps of the polymerization reaction.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
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2006年學術文章
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name
Mechanistic study of HCV polym ...... f the polymerization reaction.
@en
Mechanistic study of HCV polym ...... f the polymerization reaction.
@nl
type
label
Mechanistic study of HCV polym ...... f the polymerization reaction.
@en
Mechanistic study of HCV polym ...... f the polymerization reaction.
@nl
prefLabel
Mechanistic study of HCV polym ...... f the polymerization reaction.
@en
Mechanistic study of HCV polym ...... f the polymerization reaction.
@nl
P2093
P356
P1433
P1476
Mechanistic study of HCV polym ...... f the polymerization reaction.
@en
P2093
John Pratt
Kevin Harris
Rakesh Tripathi
Ron Pithawalla
Sudthida Vasavanonda
Todd Rockway
Warren M Kati
Wen W Jiang
P304
11312-11323
P356
10.1021/BI060511J
P407
P577
2006-09-01T00:00:00Z