about
Asymmetric synthesis of anti-1,2-amino alcohols via the Borono-Mannich reaction: a formal synthesis of (-)-swainsonineStructural reassignment of the mono- and bis-addition products from the addition reactions of N-(Diphenylmethylene)glycinate esters to [60]fullerene under Bingel conditionsNovel olanzapine analogues presenting a reduced H1 receptor affinity and retained 5HT2A/D2 binding affinity ratio.Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria.Synthesis of Bridged Heterocycles via Sequential 1,4- and 1,2-Addition Reactions to α,β-Unsaturated N-Acyliminium Ions: Mechanistic and Computational Studies.Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis.The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction.Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations.Scalemic Caged Xanthones Isolated from the Stem Bark Extract of Garcinia propinqua.Two new bioactive iridoids from Rothmannia wittii.Antimalarial Oxoprotoberberine Alkaloids from the Leaves of Miliusa cuneata.Reversal of human multi-drug resistance leukaemic cells by stemofoline derivatives via inhibition of P-glycoprotein function.Inhibition of TNF-α production in LPS-activated THP-1 monocytic cells by the crude extracts of seven Bhutanese medicinal plants.The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry.Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of phytochemicals and biological activities.Selective targeting of 2'-deoxy-5-fluorouridine to urokinase positive malignant cells in vitro.N-phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents.In vitro cytotoxicity evaluation of some substituted isatin derivatives.Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics.A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain.Bioactive compounds from the roots of Strophioblachia fimbricalyx.Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2.Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues.Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1.Synthesis of hyacinthacine B3 and purported hyacinthacine B7.Binaphthyl-based dicationic peptoids with therapeutic potential.Parviflorals A-F, trinorcadalenes and bis-trinorcadalenes from the roots of Decaschistia parviflora.Metal-catalyzed cycloisomerization reactions of cis-4-hydroxy-5-alkynylpyrrolidinones and cis-5-hydroxy-6-alkynylpiperidinones: synthesis of furo[3,2-b]pyrroles and furo[3,2-b]pyridines.Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities.Chemical diversity and anti-acne inducing bacterial potentials of essential oils from selected Elsholtzia species.Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials.Diastereoselective Ritter reactions of chiral cyclic N-acyliminium ions: synthesis of pyrido- and pyrrolo[2,3-d]oxazoles and 4-Hydroxy-5-N-acylaminopyrrolidines and 5-hydroxy-6-N-acylaminopiperidines.Concise synthesis of α-substituted 2-benzofuranmethamines and other 2-subsituted benzofurans via α-substituted 2-benzofuranmethyl carbocation intermediates.An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins.Modulation of P-glycoprotein by Stemona alkaloids in human multidrug resistance leukemic cells and structural relationships.Oxazolidinones and 2,5-Dihydrofurans via Zinc-Catalyzed Regioselective Allenylation Reactions of l-α-Amino Aldehydes.Antimalarial and cytotoxic activities of pregnene-type steroidal alkaloids from Holarrhena pubescens roots.Resolution and identification of scalemic caged xanthones from the leaf extract of Garcinia propinqua having potent cytotoxicities against colon cancer cells.Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa.Sequential 1,4- and 1,2-addition reactions to α,β-unsaturated N-acyliminium ions: a new strategy for the synthesis of spiro and bridged heterocycles.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Stephen G Pyne
@ast
Stephen G Pyne
@en
Stephen G Pyne
@es
Stephen G Pyne
@nl
Stephen G Pyne
@sl
type
label
Stephen G Pyne
@ast
Stephen G Pyne
@en
Stephen G Pyne
@es
Stephen G Pyne
@nl
Stephen G Pyne
@sl
prefLabel
Stephen G Pyne
@ast
Stephen G Pyne
@en
Stephen G Pyne
@es
Stephen G Pyne
@nl
Stephen G Pyne
@sl
P106
P21
P31
P496
0000-0003-0462-0277