about
Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processingThe histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expressionAf9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortexEpigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancerEpigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon?MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones.BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cellsTGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses.Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue.CDK9 and H2B monoubiquitination: a well-choreographed dance.Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer.Role of TIEG1 in biological processes and disease states.H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription.Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy.Usp22 deficiency impairs intestinal epithelial lineage specification in vivoBromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcriptionRelevance of Sp Binding Site Polymorphism in WWOX for Treatment Outcome in Pancreatic Cancer.SIRT2 directs the replication stress response through CDK9 deacetylation.The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene.Targeted therapy of epigenomic regulatory mechanisms controlling the epithelial to mesenchymal transition during tumor progression.Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta.Mutual antagonism of estrogen receptors alpha and beta and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines.Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene.BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire.No Significant Cytotoxic Effect of the EZH2 Inhibitor Tazemetostat (EPZ-6438) on Pediatric Glioma Cells with Wildtype Histone 3 or Mutated Histone 3.3.Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2.NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation.SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms.The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells.Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness.The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair.Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B.Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway Activity During Osteoblast Differentiation.Twist1 induces distinct cell states depending on TGFBR1-activation.RNF40 regulates gene expression in an epigenetic context-dependent manner.Regulation of osteoblastic phenotype and gene expression by hop-derived phytoestrogens.Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner.CHD1 regulates cell fate determination by activation of differentiation-induced genes.
P50
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P50
description
hulumtues
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onderzoeker
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Steven A Johnsen
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Steven A Johnsen
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Steven A Johnsen
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Steven A Johnsen
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Steven A Johnsen
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ستيفن أ يونسن
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Steven A Johnsen
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Steven A Johnsen
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Steven A Johnsen
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Steven A Johnsen
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Steven A Johnsen
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ستيفن أ يونسن
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Steven A Johnsen
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Steven A Johnsen
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Steven A Johnsen
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Steven A Johnsen
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Steven A Johnsen
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ستيفن أ يونسن
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P214
P106
P21
P214
P31
P496
0000-0003-1198-5805
P734
P735
P7859
viaf-306290653