Sodium dodecyl sulfate stability of HLA-DR1 complexes correlates with burial of hydrophobic residues in pocket 1.
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A step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cellsStaphylococcal enterotoxin A induces small clusters of HLA-DR1 on B cellsDisruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class IISusceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with PeptideExogenous antigens bind MHC class II first, and are processed by cathepsins laterAnchor side chains of short peptide fragments trigger ligand-exchange of class II MHC moleculesModel for the peptide-free conformation of class II MHC proteins.HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes.Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources.A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes.The convergent roles of tapasin and HLA-DM in antigen presentation.HLA-DO as the optimizer of epitope selection for MHC class II antigen presentation.Trans heterodimer between two non-arthritis-associated HLA alleles can predispose to arthritis in humanized miceCell-surface MHC density profiling reveals instability of autoimmunity-associated HLA.Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions.Divergent motifs but overlapping binding repertoires of six HLA-DQ molecules frequently expressed in the worldwide human population.The Thermodynamic Mechanism of Peptide-MHC Class II Complex Formation Is a Determinant of Susceptibility to HLA-DM.Anergy in peripheral memory CD4(+) T cells induced by low avidity engagement of T cell receptor.Conformational variants of class II MHC/peptide complexes induced by N- and C-terminal extensions of minimal peptide epitopes.HLA-DM recognizes the flexible conformation of major histocompatibility complex class II.HLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1.Suboptimal engagement of the T-cell receptor by a variety of peptide-MHC ligands triggers T-cell anergy.Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection.HLA-DO and Its Role in MHC Class II Antigen Presentation.HLA-DM Focuses on Conformational Flexibility Around P1 Pocket to Catalyze Peptide Exchange.Structural Insights Into HLA-DM Mediated MHC II Peptide Exchange.A novel family of human leukocyte antigen class II receptors may have its origin in archaic human speciesMajor Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation.Structural mimicry between SLA/LP and Rickettsia surface antigens as a driver of autoimmune hepatitis: insights from an in silico study.MHC class II complexes sample intermediate states along the peptide exchange pathway.Profiling MHC II immunopeptidome of blood-stage malaria reveals that cDC1 control the functionality of parasite-specific CD4 T cells.
P2860
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P2860
Sodium dodecyl sulfate stability of HLA-DR1 complexes correlates with burial of hydrophobic residues in pocket 1.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Sodium dodecyl sulfate stabili ...... rophobic residues in pocket 1.
@en
Sodium dodecyl sulfate stabili ...... rophobic residues in pocket 1.
@nl
type
label
Sodium dodecyl sulfate stabili ...... rophobic residues in pocket 1.
@en
Sodium dodecyl sulfate stabili ...... rophobic residues in pocket 1.
@nl
prefLabel
Sodium dodecyl sulfate stabili ...... rophobic residues in pocket 1.
@en
Sodium dodecyl sulfate stabili ...... rophobic residues in pocket 1.
@nl
P2093
P1476
Sodium dodecyl sulfate stabili ...... rophobic residues in pocket 1.
@en
P2093
S K Natarajan
S Sadegh-Nasseri
P304
P407
P577
1999-03-01T00:00:00Z