HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes.
about
A step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cellsMHC Class II Auto-Antigen Presentation is UnconventionalStaphylococcal enterotoxin A induces small clusters of HLA-DR1 on B cellsThe Peptide-Receptive Transition State of MHC Class I Molecules: Insight from Structure and Molecular DynamicsHLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanismConformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchangeDisruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class IISusceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with PeptideExogenous antigens bind MHC class II first, and are processed by cathepsins laterHLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptideAnchor side chains of short peptide fragments trigger ligand-exchange of class II MHC moleculesModel for the peptide-free conformation of class II MHC proteins.Identification of the transcriptional response of human intestinal mucosa to Lactobacillus plantarum WCFS1 in vivo.HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available.An unstable Th epitope of P. falciparum fosters central memory T cells and anti-CS antibody responses.Characterization of structural features controlling the receptiveness of empty class II MHC molecules.Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes.Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DMFor many but not for all: how the conformational flexibility of the peptide/MHCII complex shapes epitope selectionDivergent paths for the selection of immunodominant epitopes from distinct antigenic sources.A reductionist cell-free major histocompatibility complex class II antigen processing system identifies immunodominant epitopes.The convergent roles of tapasin and HLA-DM in antigen presentation.HLA-DO as the optimizer of epitope selection for MHC class II antigen presentation.Evaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions.The Thermodynamic Mechanism of Peptide-MHC Class II Complex Formation Is a Determinant of Susceptibility to HLA-DM.Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association.Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design.Thermodynamics of Peptide-MHC Class II Interactions: Not all Complexes are Created Equal.The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilingsHLA-DM mediates peptide exchange by interacting transiently and repeatedly with HLA-DR1.Enhanced silencing and stabilization of siRNA polyplexes by histidine-mediated hydrogen bonds.Conformational heterogeneity of MHC class II induced upon binding to different peptides is a key regulator in antigen presentation and epitope selection.Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.HLA-DM: arbiter conformationis.Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough.Structural Characteristics of HLA-DQ that May Impact DM Editing and Susceptibility to Type-1 Diabetes.HLA-DM Focuses on Conformational Flexibility Around P1 Pocket to Catalyze Peptide Exchange.Measurement of Peptide Binding to MHC Class II Molecules by Fluorescence Polarization.Structural Insights Into HLA-DM Mediated MHC II Peptide Exchange.Determinants of immunodominance for CD4 T cells.
P2860
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P2860
HLA-DM targets the hydrogen bond between the histidine at position beta81 and peptide to dissociate HLA-DR-peptide complexes.
description
2006 nî lūn-bûn
@nan
2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
HLA-DM targets the hydrogen bo ...... iate HLA-DR-peptide complexes.
@ast
HLA-DM targets the hydrogen bo ...... iate HLA-DR-peptide complexes.
@en
HLA-DM targets the hydrogen bo ...... iate HLA-DR-peptide complexes.
@nl
type
label
HLA-DM targets the hydrogen bo ...... iate HLA-DR-peptide complexes.
@ast
HLA-DM targets the hydrogen bo ...... iate HLA-DR-peptide complexes.
@en
HLA-DM targets the hydrogen bo ...... iate HLA-DR-peptide complexes.
@nl
prefLabel
HLA-DM targets the hydrogen bo ...... iate HLA-DR-peptide complexes.
@ast
HLA-DM targets the hydrogen bo ...... iate HLA-DR-peptide complexes.
@en
HLA-DM targets the hydrogen bo ...... iate HLA-DR-peptide complexes.
@nl
P2093
P2860
P356
P1433
P1476
HLA-DM targets the hydrogen bo ...... ciate HLA-DR-peptide complexes
@en
P2093
AeRyon Kim
Chih-Ling Chou
Isamu Z Hartman
Kedar Narayan
Sarat Dalai
P2860
P304
P356
10.1038/NI1414
P407
P577
2006-12-03T00:00:00Z