Targeting glutamine transport to suppress melanoma cell growth.
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Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual ScreeningTargeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour developmentAnalysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma.Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling.ASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production.Monoterpene glycoside ESK246 from Pittosporum targets LAT3 amino acid transport and prostate cancer cell growth.From Krebs to clinic: glutamine metabolism to cancer therapy.Insight into nanoparticle cellular uptake and intracellular targetingUpregulated SLC1A5 promotes cell growth and survival in colorectal cancerAttacking the supply wagons to starve cancer cells to death.Role of γ-glutamyltranspeptidase in the pathogenesis of Helicobacter suis and Helicobacter pylori infections.Synthesis and antiproliferative activity of glutamic acid-based dipeptides.L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia.Vemurafenib resistance reprograms melanoma cells towards glutamine dependence.K-Ras Activation Induces Differential Sensitivity to Sulfur Amino Acid Limitation and Deprivation and to Oxidative and Anti-Oxidative Stress in Mouse FibroblastsHigh expression of Solute Carrier Family 1, member 5 (SLC1A5) is associated with poor prognosis in clear-cell renal cell carcinomaTumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expressionTherapeutic interventions to disrupt the protein synthetic machinery in melanomaResistance to BRAF inhibitors induces glutamine dependency in melanoma cellsASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer.Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells.Inhibition of glucose metabolism prevents glycosylation of the glutamine transporter ASCT2 and promotes compensatory LAT1 upregulation in leukemia cells.Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration.Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma.Expression of glutamine metabolism-related proteins in thyroid cancer.Glutaminolysis as a target for cancer therapy.ASCT2 regulates glutamine uptake and cell growth in endometrial carcinomaGlutamine transporters in mammalian cells and their functions in physiology and cancer.Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells.LAT1 is a putative therapeutic target in endometrioid endometrial carcinoma.ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis.1,25-Dihydroxyvitamin D inhibits glutamine metabolism in Harvey-ras transformed MCF10A human breast epithelial cell.Novel therapeutic approaches targeting L-type amino acid transporters for cancer treatment.Obstacles Posed by the Tumor Microenvironment to T cell Activity: A Case for Synergistic Therapies.Engineering Tumour Cell-Binding Synthetic Polymers with Sensing Dense Transporters Associated with Aberrant Glutamine Metabolism.ρ⁰ Cells Feature De-Ubiquitination of SLC Transporters and Increased Levels and Fluxes of Amino Acids.Structure and allosteric inhibition of excitatory amino acid transporter 1.Proteomic profiling of breast cancer metabolism identifies SHMT2 and ASCT2 as prognostic factors.Increased SNAT1 is a marker of human osteosarcoma and potential therapeutic target.N-Myc downstream-regulated gene 2 restrains glycolysis and glutaminolysis in clear cell renal cell carcinoma.
P2860
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P2860
Targeting glutamine transport to suppress melanoma cell growth.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh-hant
name
Targeting glutamine transport to suppress melanoma cell growth.
@en
Targeting glutamine transport to suppress melanoma cell growth.
@nl
type
label
Targeting glutamine transport to suppress melanoma cell growth.
@en
Targeting glutamine transport to suppress melanoma cell growth.
@nl
prefLabel
Targeting glutamine transport to suppress melanoma cell growth.
@en
Targeting glutamine transport to suppress melanoma cell growth.
@nl
P2093
P50
P356
P1476
Targeting glutamine transport to suppress melanoma cell growth
@en
P2093
Danae M Sharp
Jessamy C Tiffen
John E J Rasko
Josep Font
Michelle van Geldermalsen
Mika Jormakka
Nicholas J Otte
P304
P356
10.1002/IJC.28749
P577
2014-02-17T00:00:00Z