A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding.
about
Evolution and origin of merlin, the product of the Neurofibromatosis type 2 (NF2) tumor-suppressor geneIdentification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilliThe TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase RhoStructure of dimerized radixin FERM domain suggests a novel masking motif in C-terminal residues 295-304Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domainRegulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and polyphosphatidylinositidesEzrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathwayJanus kinases and focal adhesion kinases play in the 4.1 band: a superfamily of band 4.1 domains important for cell structure and signal transductionRho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail associationCa2+-dependent binding and activation of dormant ezrin by dimeric S100PMolecular conformation of the full-length tumor suppressor NF2/Merlin--a small-angle neutron scattering studyOpen conformation of ezrin bound to phosphatidylinositol 4,5-bisphosphate and to F-actin revealed by neutron scatteringThe neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral associationNormal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockoutG protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells.Binding of moesin and ezrin to membranes containing phosphatidylinositol (4,5) bisphosphate: a comparative study of the affinity constants and conformational changes.Dephosphorylation-dependent inhibitory activity of juxtanodin on filamentous actin disassembly.Molecular analysis of microscopic ezrin dynamics by two-photon FRAP.Tailor-made ezrin actin binding domain to probe its interaction with actin in-vitro.Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neurons.Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphataseEzrin promotes morphogenesis of apical microvilli and basal infoldings in retinal pigment epithelium.Mutagenesis of the phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding site in the NH(2)-terminal domain of ezrin correlates with its altered cellular distribution.Quantitative analysis of the binding of ezrin to large unilamellar vesicles containing phosphatidylinositol 4,5 bisphosphate.Giant unilamellar vesicles containing phosphatidylinositol(4,5)bisphosphate: characterization and functionalityReplacement of threonine 558, a critical site of phosphorylation of moesin in vivo, with aspartate activates F-actin binding of moesin. Regulation by conformational change.Phosphoinositides regulate membrane-dependent actin assembly by latex bead phagosomes.Ezrin promotes actin assembly at the phagosome membrane and regulates phago-lysosomal fusion.Involvement of ezrin/moesin in de novo actin assembly on phagosomal membranes.G protein-coupled receptor kinase 2-mediated phosphorylation of ezrin is required for G protein-coupled receptor-dependent reorganization of the actin cytoskeleton.Self-assembly of actin scaffolds at ponticulin-containing supported phospholipid bilayers.Expression level, subcellular distribution and rho-GDI binding affinity of merlin in comparison with Ezrin/Radixin/Moesin proteins.The amino-terminal domains of the ezrin, radixin, and moesin (ERM) proteins bind advanced glycation end products, an interaction that may play a role in the development of diabetic complications.The carboxyl-terminal region of EBP50 binds to a site in the amino-terminal domain of ezrin that is masked in the dormant molecule.Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlin.Ezrin regulates the expression of Mrp2/Abcc2 and Mdr1/Abcb1 along the rat small intestinal tract.Altered expression of ezrin in esophageal squamous cell carcinoma.
P2860
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P2860
A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding.
@en
A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding.
@nl
type
label
A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding.
@en
A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding.
@nl
prefLabel
A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding.
@en
A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding.
@nl
P2093
P2860
P356
P1476
A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding.
@en
P2093
P2860
P304
20088-20095
P356
10.1074/JBC.272.32.20088
P407
P577
1997-08-01T00:00:00Z