Expression level, subcellular distribution and rho-GDI binding affinity of merlin in comparison with Ezrin/Radixin/Moesin proteins. - Wikidata - wikimedia - TriplyDB

Expression level, subcellular distribution and rho-GDI binding affinity of merlin in comparison with Ezrin/Radixin/Moesin proteins.

Expression level, subcellular distribution and rho-GDI binding affinity of merlin in comparison with Ezrin/Radixin/Moesin proteins.

http://www.wikidata.org/entity/Q42810844

about

Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2 Binding of the merlin-I product of the neurofibromatosis type 2 tumour suppressor gene to a novel site in beta-fodrin is regulated by association between merlin domains The 'invisible hand': regulation of RHO GTPases by RHOGDIs Neurofibromatosis type 2 A neuronal function of the tumor suppressor protein merlin Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain Quantitative Analysis of Prenylated RhoA Interaction with Its Chaperone, RhoGDI Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain Organizing the cell cortex: the role of ERM proteins Merlin, a "magic" linker between extracellular cues and intracellular signaling pathways that regulate cell motility, proliferation, and survival Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions Phosphorylation of podocalyxin (Ser415) Prevents RhoA and ezrin activation and disrupts its interaction with the actin cytoskeleton.Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane.Molecular mechanisms promoting the pathogenesis of Schwann cell neoplasms Characterization of a novel intracellular heparanase that has a FERM domain.Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP.Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation Functional analysis of the neurofibromatosis type 2 protein by means of disease-causing point mutations Apical membrane segregation of phosphatidylinositol-4,5-bisphosphate influences parathyroid hormone 1 receptor compartmental signaling and localization via direct regulation of ezrin in LLC-PK1 cells Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing Osmotic stress and the cytoskeleton: the R(h)ole of Rho GTPases.Modeling NF2 with human arachnoidal and meningioma cell culture systems: NF2 silencing reflects the benign character of tumor growth.Outer dense fiber 2 is a widespread centrosome scaffold component preferentially associated with mother centrioles: its identification from isolated centrosomes Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex.Conserved sequence repeats of IQGAP1 mediate binding to Ezrin Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy.The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells.Isolation and characterization of an aggresome determinant in the NF2 tumor suppressor.Regulatory models of RhoA suppression by dematin, a cytoskeletal adaptor protein.EphrinB1 promotes cancer cell migration and invasion through the interaction with RhoGDI1.Regulation of the neurofibromatosis 2 gene promoter expression during embryonic development.Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlin.

P2860

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P2860

Expression level, subcellular distribution and rho-GDI binding affinity of merlin in comparison with Ezrin/Radixin/Moesin proteins.

http://www.wikidata.org/entity/Q42810844

description

1999 nî lūn-bûn

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1999年の論文

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年学术文章

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1999年學術文章

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1999年學術文章

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1999年學術文章

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name

Expression level, subcellular ...... Ezrin/Radixin/Moesin proteins.

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Expression level, subcellular ...... Ezrin/Radixin/Moesin proteins.

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type

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Expression level, subcellular ...... Ezrin/Radixin/Moesin proteins.

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Expression level, subcellular ...... Ezrin/Radixin/Moesin proteins.

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prefLabel

Expression level, subcellular ...... Ezrin/Radixin/Moesin proteins.

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Expression level, subcellular ...... Ezrin/Radixin/Moesin proteins.

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Expression level, subcellular ...... Ezrin/Radixin/Moesin proteins.

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Imamura M

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Maeda M

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Matsui T

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Tsukita S

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P2860

The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

NHE3 kinase A regulatory protein E3KARP binds the epithelial brush border Na+/H+ exchanger NHE3 and the cytoskeletal protein ezrin

A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins

NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins

Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site

Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2

ERM (ezrin/radixin/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis

Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family

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4788-4797

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10.1038/SJ.ONC.1202871

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34

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18

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