Influence of interleukin-6 (IL-6) dimerization on formation of the high affinity hexameric IL-6.receptor complex. - Wikidata - wikimedia - TriplyDB

Influence of interleukin-6 (IL-6) dimerization on formation of the high affinity hexameric IL-6.receptor complex.

Influence of interleukin-6 (IL-6) dimerization on formation of the high affinity hexameric IL-6.receptor complex.

http://www.wikidata.org/entity/Q54582911

about

Evolutionary divergence and functions of the human interleukin (IL) gene family The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling Function and molecular modeling of the interaction between human interleukin 6 and its HNK-1 oligosaccharide ligands Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor Receptor recognition by gp130 cytokines.Signaling through a novel domain of gp130 mediates cell proliferation and activation of Hck and Erk kinases.Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130.Interleukin-6: structure-function relationships.The immunoglobulin-like module of gp130 is required for signaling by interleukin-6, but not by leukemia inhibitory factor.Roles of IL-6 in Ocular Inflammation: A Review.Involvement of corneal epithelial cells in the Th17 response in an in vitro bacterial inflammation model.Dual signaling role of the protein tyrosine phosphatase SHP-2 in regulating expression of acute-phase plasma proteins by interleukin-6 cytokine receptors in hepatic cells.Replacing factor-dependency with that for lysozyme: affordable culture of IL-6-dependent hybridoma by transfecting artificial cell surface receptor.Carbohydrate recognition site of interleukin-2 in relation to cell proliferation.Growth control of hybridoma cells with an artificially induced EpoR-gp130 heterodimer.Mechanistic pharmacokinetic/target engagement/pharmacodynamic (PK/TE/PD) modeling in deciphering interplay between a monoclonal antibody and its soluble target in cynomolgus monkeys.Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane.The N-terminus of gp130 is critical for the formation of the high-affinity interleukin-6 receptor complex.Recombinant human single chain Fv antibodies recognizing human interleukin-6. Specific targeting of cytokine-secreting cells.Characterization of an Antagonist Interleukin-6 Dimer by Stable Isotope Labeling, Cross-linking, and Mass Spectrometry

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P2860

Influence of interleukin-6 (IL-6) dimerization on formation of the high affinity hexameric IL-6.receptor complex.

http://www.wikidata.org/entity/Q54582911

description

1996 nî lūn-bûn

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1996年の論文

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1996年学术文章

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1996年学术文章

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1996年学术文章

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1996年学术文章

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1996年学术文章

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1996年學術文章

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1996年學術文章

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1996年學術文章

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name

Influence of interleukin-6 (IL ...... xameric IL-6.receptor complex.

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Influence of interleukin-6

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type

label

Influence of interleukin-6 (IL ...... xameric IL-6.receptor complex.

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Influence of interleukin-6

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prefLabel

Influence of interleukin-6 (IL ...... xameric IL-6.receptor complex.

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Influence of interleukin-6

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Journal of Biological Chemistry

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Influence of interleukin-6 (IL ...... exameric IL-6.receptor complex

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A Hammacher

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E C Nice

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L D Ward

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R L Moritz

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P2860

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor

Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex

Molecular cloning and expression of an IL-6 signal transducer, gp130

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

Cytokine signal transduction

IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor

Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor

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20138-20144

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33

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Richard Simpson

Jacqueline M Matthews

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