WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe.
about
Mutational profiling of kinases in glioblastoma.Translational Research to Improve the Efficacy of Carbon Ion Radiotherapy: Experience of Gunma UniversityEffects of Brassicaceae Isothiocyanates on Prostate CancerTargeting the Mitotic Catastrophe Signaling Pathway in CancerCross talk of tyrosine kinases with the DNA damage signaling pathwaysCurrent and future trials of targeted therapies in cutaneous melanomaGenome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like CellsA haploid genetic screen identifies the G1/S regulatory machinery as a determinant of Wee1 inhibitor sensitivity.WEE1 kinase polymorphism as a predictive biomarker for efficacy of platinum-gemcitabine doublet chemotherapy in advanced non-small cell lung cancer patients.PLK1, A Potential Target for Cancer TherapyWee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomasWee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapyChk1 inhibition in p53-deficient cell lines drives rapid chromosome fragmentation followed by caspase-independent cell deathExpression and prognostic value of the WEE1 kinase in gliomas.Overexpression of cell cycle regulator CDCA3 promotes oral cancer progression by enhancing cell proliferation with prevention of G1 phase arrest.Functional kinomics identifies candidate therapeutic targets in head and neck cancerDisruption of Pten speeds onset and increases severity of spontaneous colitis in Il10(-/-) miceCombined inhibition of Chk1 and Wee1: in vitro synergistic effect translates to tumor growth inhibition in vivo.High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapyWEE1 tyrosine kinase, a novel epigenetic modifierIdentification of a Wee1-like kinase gene essential for procyclic Trypanosoma brucei survival.Efficient induction of apoptosis by wee1 kinase inhibition in hepatocellular carcinoma cells.A regimen combining the Wee1 inhibitor AZD1775 with HDAC inhibitors targets human acute myeloid leukemia cells harboring various genetic mutations.Targeting cell cycle regulators in hematologic malignancies.WEE1 inhibition sensitizes basal breast cancer cells to TRAIL-induced apoptosis.Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescence.Identification of Phosphorylated Cyclin-Dependent Kinase 1 Associated with Colorectal Cancer Survival Using Label-Free Quantitative Analyses.Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins.Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies.Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibitionChemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition.Identification of aurora kinase B and Wee1-like protein kinase as downstream targets of (V600E)B-RAF in melanoma.MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1PAXIP1 Potentiates the Combination of WEE1 Inhibitor AZD1775 and Platinum Agents in Lung Cancer.Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) EraStrategies for optimizing the response of cancer and normal tissues to radiation.Targeting the WEE1 kinase as a molecular targeted therapy for gastric cancer.Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma.Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading.Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication.
P2860
Q21261249-2A1F2C37-00D6-46FB-861B-400C55B07915Q26744799-8628F4AB-A211-49BD-A8A9-3464494E59EAQ26749086-2E0D023E-EDC5-496B-9D85-52A401761BE1Q26778544-AFB89911-EBF9-436D-80CB-B47CBBA21404Q26778614-27B3DF17-89B3-4737-85C9-31E20E36DADFQ27022355-C783B289-8E5D-40F7-8DF3-34966A867E35Q27320024-0923D6D5-5EBC-4E4A-B0ED-44FFD71288EEQ27323300-45C05A02-C22C-4CFA-A7CC-92113879C8AFQ27853174-87B58209-C26A-4898-9E63-2C9F6C82A702Q28078772-8C70C14D-EC75-4AAB-B640-DD2700323C9BQ28487835-8ADE01EA-7404-4AF5-ABC7-F691BC3782EFQ28833606-6C6B0F80-32F8-4777-BEFF-CD244EF34954Q30570001-C6BADF35-13EA-47DD-852B-5B45F95C7802Q30570389-53F5C62A-95E9-4811-AC0B-FB533E520567Q31077436-0E6D6F6E-9B0A-4010-BBF1-4FCCFB3CC4B2Q34055936-033FC46F-6C04-4A80-A416-570E9B314044Q34084483-87E24F0C-FBE5-4276-80BB-90DF9FE39F1EQ34309214-EFFF0817-E3D8-44DF-80AE-3D94264092D7Q34311842-A6CD1455-3A30-4AFC-8DA2-601B04236C7BQ34335765-2973F5A1-AA84-4EF5-9341-25BCA7146F8DQ35041275-CDE0E4FA-DEE0-424E-B643-90D0E3485488Q35194021-58D1C5ED-739A-433A-AEA5-54CE566CFC8FQ35287823-9257A04D-F687-4949-86CD-0E8A5001CF69Q35334436-2BEC9382-E0D4-413B-A0E9-F89FFD621D71Q35683131-AC010E46-DE55-40BB-807E-CE02AB857B32Q36020559-BA7D22F0-37A8-4ADB-8A5B-2090CD4D0532Q36069009-E4FB1CE0-0565-4EC9-8BFE-A09FE7363CD7Q36244669-04AB0320-FC5A-439F-9120-9BF389B277B1Q36341628-B719BEDD-8B20-492D-9B8B-625335614274Q36454659-61E7F7F0-2AE5-438B-A512-6334845BF0CFQ36546455-21D28A97-74C7-457B-9A16-27831D9C7808Q36750123-3C8BB9D3-AD01-489C-BD87-0B30ECB063A4Q36766761-260DC997-767D-4CC3-8909-A995A49C9B7FQ37075297-7740DBF4-C7AF-4B6A-9528-FD23BEDA780EQ37118895-8AB2A7D5-6972-48D7-B6D1-4141B998A19DQ37531724-A9CFF7E7-0013-4CC0-A3BB-7A3E0E690E94Q37580332-4624FC55-BD4A-4188-982A-384A91BFD0EBQ37704849-532C6DE1-37D2-4D98-BB9A-4B8B7B91A52AQ37706861-939E9EB6-FD73-453D-B988-B9C347B7E141Q37936675-3D2C0BBC-FDD3-4747-B252-D45C9EAE03DE
P2860
WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
WEE1 kinase targeting combined ...... catalyzes mitotic catastrophe.
@en
WEE1 kinase targeting combined ...... catalyzes mitotic catastrophe.
@nl
type
label
WEE1 kinase targeting combined ...... catalyzes mitotic catastrophe.
@en
WEE1 kinase targeting combined ...... catalyzes mitotic catastrophe.
@nl
prefLabel
WEE1 kinase targeting combined ...... catalyzes mitotic catastrophe.
@en
WEE1 kinase targeting combined ...... catalyzes mitotic catastrophe.
@nl
P2093
P1476
WEE1 kinase targeting combined ...... catalyzes mitotic catastrophe.
@en
P2093
Cornelis J F Van Noorden
David Noske
Shahryar E Mir
Tom Würdinger
P304
P356
10.1158/1078-0432.CCR-10-2537
P407
P577
2011-05-11T00:00:00Z