Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation.
about
Recent Progress in Therapeutic Treatments and Screening Strategies for the Prevention and Treatment of HPV-Associated Head and Neck CancerRINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesisTargeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myelomaRITA displays anti-tumor activity in medulloblastomas independent of TP53 status.GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers.Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck.New molecular targets against cervical cancer.Small molecule inhibitors of human papillomavirus protein - protein interactions.Wild type p53 reactivation: from lab bench to clinic.RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53abnormal myeloma cells independently of the p53 pathway.Inhibition of glycolytic enzymes mediated by pharmacologically activated p53: targeting Warburg effect to fight cancer.Genetic variants of a BH3-only pro-apoptotic gene, PUMA, and risk of HPV16-associated squamous cell carcinoma of the head and neckProteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-gingerol in cervical cancer cells.Nip the HPV encoded evil in the cancer bud: HPV reshapes TRAILs and signaling landscapesTargeting the p53 pathway.Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124.Selective antitumor activity of roscovitine in head and neck cancer.Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma.Emerging drugs for cervical cancer.Pharmacological reactivation of p53 as a strategy to treat cancer.Emerging drugs for the treatment of cervical cancer.Restoration of tumor suppressor p53 by differentially regulating pro- and anti-p53 networks in HPV-18-infected cervical cancer cells.Compensated pathogenic deviations.Mathematical Modeling of E6-p53 interactions in Cervical CancerA High-Throughput Cell-Based Screen Identified a 2-[(E)-2-Phenylvinyl]-8-Quinolinol Core Structure That Activates p53.RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38.Rb/E2F1 regulates the innate immune receptor Toll-like receptor 3 in epithelial cells.RITA enhances chemosensivity of pre-B ALL cells to doxorubicin by inducing p53-dependent apoptosis.A quantitative LumiFluo assay to test inhibitory compounds blocking p53 degradation induced by human papillomavirus oncoprotein E6 in living cells.
P2860
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P2860
Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
Rescue of p53 function by smal ...... cking E6-mediated degradation.
@en
Rescue of p53 function by smal ...... cking E6-mediated degradation.
@nl
type
label
Rescue of p53 function by smal ...... cking E6-mediated degradation.
@en
Rescue of p53 function by smal ...... cking E6-mediated degradation.
@nl
prefLabel
Rescue of p53 function by smal ...... cking E6-mediated degradation.
@en
Rescue of p53 function by smal ...... cking E6-mediated degradation.
@nl
P1433
P1476
Rescue of p53 function by smal ...... ocking E6-mediated degradation
@en
P2093
Carolyn Ying Zhao
Wenjie Bao
P304
P356
10.1158/0008-5472.CAN-09-2787
P407
P577
2010-04-01T00:00:00Z