Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

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Progress in the Development of non-BET Bromodomain Chemical Probes.Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology.Chemical probes and inhibitors of bromodomains outside the BET family.

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Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

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Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

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Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

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Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

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Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

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Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

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P1476

Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

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Catherine M. Rogers

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Christopher J. Schofield

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Cynthia Tallant

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Duncan A. Hay

http://www.w3.org/2001/XMLSchema#string

Octovia P. Monteiro

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Oleg Fedorov

http://www.w3.org/2001/XMLSchema#string

Paul E. Brennan

http://www.w3.org/2001/XMLSchema#string

Sarah Martin

http://www.w3.org/2001/XMLSchema#string

Stefan Knapp

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P2860

The transcriptional regulation role of BRD7 by binding to acetylated histone through bromodomain

Selective inhibition of BET bromodomains

BRD7 is a candidate tumour suppressor gene required for p53 function

Histone recognition and large-scale structural analysis of the human bromodomain family

BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells

Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence

BRD7, a novel bromodomain gene, inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways.

Target validation using chemical probes.

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1381-1386

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scholarly article

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10.1039/C5MD00152H

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P478

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Susanne Müller

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2015-01-01T00:00:00Z

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Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

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P2860

P2860

Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

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P1433

P1476

P2093

P2860

P304

P31

P356

P433

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P577

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

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P50

P577