A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling.
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DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of ElongatorTissue-specific reduction in splicing efficiency of IKBKAP due to the major mutation associated with familial dysautonomia.The emerging role of acetylation in the regulation of autophagyDefects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutantsThe Many Faces of Elongator in Neurodevelopment and DiseaseIntegrative assessment of chlorine-induced acute lung injury in miceFamilial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP DownregulationJNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamineA neuron autonomous role for the familial dysautonomia gene ELP1 in sympathetic and sensory target tissue innervation.The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation.The familial dysautonomia disease gene IKBKAP is required in the developing and adult mouse central nervous systemOlfactory stem cells, a new cellular model for studying molecular mechanisms underlying familial dysautonomiaPhosphatidylserine increases IKBKAP levels in familial dysautonomia cellsElongator complex influences telomeric gene silencing and DNA damage response by its role in wobble uridine tRNA modification.Deletion of exon 20 of the Familial Dysautonomia gene Ikbkap in mice causes developmental delay, cardiovascular defects, and early embryonic lethalityIKAP/Elp1 is required in vivo for neurogenesis and neuronal survival, but not for neural crest migration.Defects in tongue papillae and taste sensation indicate a problem with neurotrophic support in various neurological diseases.RETRACTED: Identification of an RNA-dependent RNA polymerase in Drosophila involved in RNAi and transposon suppressionDepletion of the IKBKAP ortholog in zebrafish leads to hirschsprung disease-like phenotype.IKAP deficiency in an FD mouse model and in oligodendrocyte precursor cells results in downregulation of genes involved in oligodendrocyte differentiation and myelin formation.Specific correction of a splice defect in brain by nutritional supplementation.Involvement of IKAP in peripheral target innervation and in specific JNK and NGF signaling in developing PNS neurons.Archaeal Elp3 catalyzes tRNA wobble uridine modification at C5 via a radical mechanism.Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia.IKAP expression levels modulate disease severity in a mouse model of familial dysautonomia.Molecular genetics of hereditary sensory neuropathies.Axon Transport and Neuropathy: Relevant Perspectives on the Etiopathogenesis of Familial Dysautonomia.Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP.Loss-of-function of IKAP/ELP1: could neuronal migration defect underlie familial dysautonomia?Familial Dysautonomia: Mechanisms and ModelsThe tale of protein lysine acetylation in the cytoplasm.Protein–protein interactions and selection: yeast-based approaches that exploit guanine nucleotide-binding protein signaling.Functional characterization of SAMD9, a protein deficient in normophosphatemic familial tumoral calcinosis.Biomphalaria glabrata transcriptome: identification of cell-signalling, transcriptional control and immune-related genes from open reading frame expressed sequence tags (ORESTES).Cardiac glycosides correct aberrant splicing of IKBKAP-encoded mRNA in familial dysautonomia derived cells by suppressing expression of SRSF3.Herpes simplex virus type 1 ICP27-dependent activation of NF-kappaB.A novel c-Jun N-terminal kinase (JNK)-binding protein WDR62 is recruited to stress granules and mediates a nonclassical JNK activation.Identification and analysis of a novel dimerization domain shared by various members of c-Jun N-terminal kinase (JNK) scaffold proteins.Androgen-sensitive microsomal signaling networks coupled to the proliferation and differentiation of human prostate cancer cells.Docking interactions of the JNK scaffold protein WDR62.
P2860
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P2860
A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
A novel specific role for I ka ...... in cytosolic stress signaling.
@en
A novel specific role for I ka ...... in cytosolic stress signaling.
@nl
type
label
A novel specific role for I ka ...... in cytosolic stress signaling.
@en
A novel specific role for I ka ...... in cytosolic stress signaling.
@nl
prefLabel
A novel specific role for I ka ...... in cytosolic stress signaling.
@en
A novel specific role for I ka ...... in cytosolic stress signaling.
@nl
P2093
P2860
P50
P356
P1476
A novel specific role for I ka ...... in cytosolic stress signaling.
@en
P2093
Sigal Katz
Thomas Herdegen
Tuula Kallunki
P2860
P304
31918-31928
P356
10.1074/JBC.M200719200
P407
P577
2002-06-10T00:00:00Z