The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.
about
Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesisCrystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancerSerine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dubé gene productInteraction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) proteinTumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signalingBHD mutations, clinical and molecular genetic investigations of Birt-Hogg-Dubé syndrome: a new series of 50 families and a review of published reportsKidney-targeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneysDeficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasiaThe role of the Birt-Hogg-Dubé protein in mTOR activation and renal tumorigenesisLoss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcriptionFolliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK.Folliculin mutations are not associated with severe COPD.Topical rapamycin as a treatment for fibrofolliculomas in Birt-Hogg-Dubé syndrome: a double-blind placebo-controlled randomized split-face trial.Negative regulation of EGFR signalling by the human folliculin tumour suppressor proteinFolliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion.Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells.Human folliculin delays cell cycle progression through late S and G2/M-phases: effect of phosphorylation and tumor associated mutationsPulmonary manifestations of Birt-Hogg-Dubé syndrome.The folliculin mutation database: an online database of mutations associated with Birt-Hogg-Dubé syndromeFLCN Maintains the Leucine Level in Lysosome to Stimulate mTORC1.Clinical Features, Genetics and Potential Therapeutic Approaches for Birt-Hogg-Dubé Syndrome.Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein.The Birt-Hogg-Dubé tumor suppressor Folliculin negatively regulates ribosomal RNA synthesisFlcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression.Multiple amino acid sensing inputs to mTORC1.Birt-Hogg-Dubé syndrome: from gene discovery to molecularly targeted therapies.Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure.Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPasesAbsence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibilityThe folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1.Molecular genetics and clinical features of Birt-Hogg-Dubé syndrome.Birt-Hogg-Dubé syndrome and the skin.Rag GTPase in amino acid signaling.Birt-Hogg-Dubé Syndrome: A Review of Dermatological Manifestations and Other Symptoms.FLCN: The causative gene for Birt-Hogg-Dubé syndrome.H255Y and K508R missense mutations in tumour suppressor folliculin (FLCN) promote kidney cell proliferation.Constitutional FLCN mutations in patients with suspected Birt-Hogg-Dubé syndrome ascertained for non-cutaneous manifestations
P2860
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P2860
The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
The Birt-Hogg-Dube and tuberou ...... in Schizosaccharomyces pombe.
@en
The Birt-Hogg-Dube and tuberou ...... in Schizosaccharomyces pombe.
@nl
type
label
The Birt-Hogg-Dube and tuberou ...... in Schizosaccharomyces pombe.
@en
The Birt-Hogg-Dube and tuberou ...... in Schizosaccharomyces pombe.
@nl
prefLabel
The Birt-Hogg-Dube and tuberou ...... in Schizosaccharomyces pombe.
@en
The Birt-Hogg-Dube and tuberou ...... in Schizosaccharomyces pombe.
@nl
P2093
P2860
P921
P356
P1476
The Birt-Hogg-Dube and tuberou ...... in Schizosaccharomyces pombe.
@en
P2093
Damir Khabibullin
Elizabeth Petri Henske
Emmanuelle Nicolas
Marjon van Slegtenhorst
Tiffiney R Hartman
Warren D Kruger
P2860
P304
24583-24590
P356
10.1074/JBC.M700857200
P407
P577
2007-06-07T00:00:00Z