Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes.
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Mechanism by which metformin reduces glucose production in type 2 diabetesCellular and molecular mechanisms of metformin: an overviewNew promises for metformin: advances in the understanding of its mechanisms of actionBifunctional homodimeric triokinase/FMN cyclase: contribution of protein domains to the activities of the human enzyme and molecular dynamics simulation of domain movementsThe mitochondrial consequences of uncoupling intact cells depend on the nature of the exogenous substrateMetformin impairs mitochondrial function in skeletal muscle of both lean and diabetic rats in a dose-dependent mannerExogenous Mg-ATP induces a large inhibition of pyruvate kinase in intact rat hepatocytesEvidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chainMetformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogsMetformin revisited: re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents.The desert gerbil Psammomys obesus as a model for metformin-sensitive nutritional type 2 diabetes to protect hepatocellular metabolic damage: Impact of mitochondrial redox stateReview article: Drug therapy for non-alcoholic fatty liver disease.Effects of glycemic control on glucose utilization and mitochondrial respiration during resuscitated murine septic shock.Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.Effects of metformin on burn-induced hepatic endoplasmic reticulum stress in male ratsLC-MS proteomics analysis of the insulin/IGF-1-deficient Caenorhabditis elegans daf-2(e1370) mutant reveals extensive restructuring of intermediary metabolism.Overview of metformin: special focus on metformin extended release.Impaired noradrenaline-induced lipolysis in white fat of aP2-Ucp1 transgenic mice is associated with changes in G-protein levels.Metformin improves postprandial glucose homeostasis in rainbow trout fed dietary carbohydrates: a link with the induction of hepatic lipogenic capacities?Glycolytic glioma cells with active glycogen synthase are sensitive to PTEN and inhibitors of PI3K and gluconeogenesis.Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study.Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate.Adenovirus-mediated overexpression of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in gluconeogenic rat hepatoma cells. Paradoxical effect on Fru-2,6-P2 levels.Current and novel therapies for the treatment of nonalcoholic steatohepatitis.Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.Uncoupling effect of polyunsaturated fatty acid deficiency in isolated rat hepatocytes:effect on glycerol metabolism.Inhibition of glycerol metabolism in hepatocytes isolated from endotoxic rats.Effects of metformin on glucose metabolism of perfused rat livers.Glucose 6-phosphate hydrolysis is activated by glucagon in a low temperature-sensitive manner.Inverse relationship between peripheral insulin removal and action: studies with metformin.Application of (13)C-filtered (1)H NMR to evaluate drug action on gluconeogenesis and glycogenolysis simultaneously in isolated rat hepatocytes.Changes in one-carbon metabolism after duodenal-jejunal bypass surgery.Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats.
P2860
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P2860
Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes.
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1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh-hant
name
Metformin decreases gluconeoge ...... x in isolated rat hepatocytes.
@en
Metformin decreases gluconeoge ...... x in isolated rat hepatocytes.
@nl
type
label
Metformin decreases gluconeoge ...... x in isolated rat hepatocytes.
@en
Metformin decreases gluconeoge ...... x in isolated rat hepatocytes.
@nl
prefLabel
Metformin decreases gluconeoge ...... x in isolated rat hepatocytes.
@en
Metformin decreases gluconeoge ...... x in isolated rat hepatocytes.
@nl
P2093
P2860
P1433
P1476
Metformin decreases gluconeoge ...... x in isolated rat hepatocytes.
@en
P2093
N Wiernsperger
X M Leverve
P2860
P304
P356
10.1111/J.1432-1033.1993.TB17886.X
P407
P577
1993-05-01T00:00:00Z