about
ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expressionDiphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascadeRad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast.Use of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performanceExpression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscleDual functions of ASCIZ in the DNA base damage response and pulmonary organogenesisASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage.The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2.SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins.Mdt1 facilitates efficient repair of blocked DNA double-strand breaks and recombinational maintenance of telomeres.The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim.Suppression of chromosome healing and anticheckpoint pathways in yeast postsenescence survivors.Molecular basis of the essential s phase function of the rad53 checkpoint kinase.Yeast hEST1A/B (SMG5/6)-like proteins contribute to environment-sensing adaptive gene expression responsesDNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion.Molecular basis for lysine specificity in the yeast ubiquitin-conjugating enzyme Cdc34.The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma.Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms.Quantitative Analysis of Yeast Checkpoint Protein Kinase Activity by Combined Mass Spectrometry Enzyme Assays.Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.Multivalency regulates activity in an intrinsically disordered transcription factor.Multivalency regulates activity in an intrinsically disordered transcription factorCrystallization and preliminary X-ray diffraction studies of FHA domains of Dun1 and Rad53 protein kinasesThe ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivityATMIN (ATM Interactor)A breathtaking phenotype: Unexpected roles of the DNA base damage response protein ASCIZ as a key regulator of early lung developmentNMR structure of yeast Dun1 FHA domainSynapsins as major neuronal Ca2+/S100A1-interacting proteinsExpression of neural BC1 RNA: Induction in murine tumoursATP-dependent helicase activity is dispensable for the physiological functions of Recql4
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Jörg Heierhorst
@ast
Jörg Heierhorst
@en
Jörg Heierhorst
@es
Jörg Heierhorst
@nl
Jörg Heierhorst
@sl
type
label
Jörg Heierhorst
@ast
Jörg Heierhorst
@en
Jörg Heierhorst
@es
Jörg Heierhorst
@nl
Jörg Heierhorst
@sl
prefLabel
Jörg Heierhorst
@ast
Jörg Heierhorst
@en
Jörg Heierhorst
@es
Jörg Heierhorst
@nl
Jörg Heierhorst
@sl
P106
P21
P31
P496
0000-0003-2789-9514