Molecular basis of the essential s phase function of the rad53 checkpoint kinase. - Wikidata - wikimedia - TriplyDB

Molecular basis of the essential s phase function of the rad53 checkpoint kinase.

Molecular basis of the essential s phase function of the rad53 checkpoint kinase.

http://www.wikidata.org/entity/Q37122913

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Use of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.Increased and imbalanced dNTP pools symmetrically promote both leading and lagging strand replication infidelity Mutations in the Non-Catalytic Subunit Dpb2 of DNA Polymerase Epsilon Affect the Nrm1 Branch of the DNA Replication Checkpoint.S phase block following MEC1ATR inactivation occurs without severe dNTP depletion.Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress Mec1/ATR, the Program Manager of Nucleic Acids Inc.Early Loss of Telomerase Action in Yeast Creates a Dependence on the DNA Damage Response Adaptor Proteins.Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts.

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Molecular basis of the essential s phase function of the rad53 checkpoint kinase.

http://www.wikidata.org/entity/Q37122913

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 10 June 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Molecular basis of the essential s phase function of the rad53 checkpoint kinase.

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Molecular basis of the essential s phase function of the rad53 checkpoint kinase.

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type

label

Molecular basis of the essential s phase function of the rad53 checkpoint kinase.

@en

Molecular basis of the essential s phase function of the rad53 checkpoint kinase.

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prefLabel

Molecular basis of the essential s phase function of the rad53 checkpoint kinase.

@en

Molecular basis of the essential s phase function of the rad53 checkpoint kinase.

@nl

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Molecular and Cellular Biology

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Molecular basis of the essential s phase function of the rad53 checkpoint kinase.

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Alessandro Fazio

http://www.w3.org/2001/XMLSchema#string

Andrew Hammet

http://www.w3.org/2001/XMLSchema#string

Eric S-W Chen

http://www.w3.org/2001/XMLSchema#string

Shun-Chung Wang

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P2860

Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair

Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade

Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast.

NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae.

Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks.

The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.

SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.

Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks.

The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor.

Mrc1 transduces signals of DNA replication stress to activate Rad53.

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3202-3213

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scholarly article

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10.1128/MCB.00474-13

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16

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33

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Jörg Heierhorst

Achille Pellicioli

Robert Buckland

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2013-06-10T00:00:00Z

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237098159

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3753913

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