about
Cish actively silences TCR signaling in CD8+ T cells to maintain tumor toleranceOxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.Type I cytokines synergize with oncogene inhibition to induce tumor growth arrest.miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.Reprogramming antitumor immunityAkt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy.The transcription factor BACH2 promotes tumor immunosuppression.Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis.BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancersIonic immune suppression within the tumour microenvironment limits T cell effector function.Novel "Elements" of Immune Suppression within the Tumor Microenvironment.Inhibition of the T cell oxygen sensing machinery promotes anti-tumor efficacy.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
David Clever
@ast
David Clever
@en
David Clever
@es
David Clever
@nl
David Clever
@sl
type
label
David Clever
@ast
David Clever
@en
David Clever
@es
David Clever
@nl
David Clever
@sl
prefLabel
David Clever
@ast
David Clever
@en
David Clever
@es
David Clever
@nl
David Clever
@sl
P106
P1153
6504104675
P21
P31
P496
0000-0002-9137-8177