The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers
about
The ubiquitin ligase HACE1 regulates Golgi membrane dynamics during the cell cycleUbiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppressionA BEN-domain-containing protein associates with heterochromatin and represses transcriptionHACE1 deficiency causes an autosomal recessive neurodevelopmental syndrome.The E3 ubiquitin ligase Hace1 is required for early embryonic development in Xenopus laevis.Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastomaFrequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor.Endocytic regulation of alkali metal transport proteins in mammals, yeast and plants.Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal typeNKX6.3 Regulates Reactive Oxygen Species Production by Suppressing NF-kB and DNMT1 Activities in Gastric Epithelial Cells.Extranodal NK/T-cell lymphoma: toward the identification of clinical molecular targetsMethylome analysis identifies a Wilms tumor epigenetic biomarker detectable in blood.Comparative methylome analysis identifies new tumour subtypes and biomarkers for transformation of nephrogenic rests into Wilms tumourLoss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addictionMetabolic context regulates distinct hypothalamic transcriptional responses to antiaging interventionsLoss of the E3 ubiquitin ligase HACE1 results in enhanced Rac1 signaling contributing to breast cancer progression.Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype.HACE1 is a tumor suppressor gene candidate in natural killer cell neoplasmsCell cycle regulation of Golgi membrane dynamics.HACE1 Negatively Regulates Virus-Triggered Type I IFN Signaling by Impeding the Formation of the MAVS-TRAF3 Complex.The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.HACE1: A novel repressor of RAR transcriptional activity.Lin28 promotes transformation and is associated with advanced human malignancies.HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.Common variations within HACE1 gene and neuroblastoma susceptibility in a Southern Chinese population.Ubiquitylation of active Rac1 by the E3 ubiquitin-ligase HACE1.Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.Peripheral T-cell and NK cell lymphoproliferative disorders: cell of origin, clinical and pathological implications.HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.E3 ubiquitin ligases in regulating stress fiber, lamellipodium, and focal adhesion dynamics.The genetic factors contributing to the development of Wilm's tumor and their clinical utility in its diagnosis and prognosis.Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors.Epigenetic regulation of ANKRD18B in lung cancer.Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes.Genetic susceptibility to neuroblastoma.A genomic survey of HECT ubiquitin ligases in eukaryotes reveals independent expansions of the HECT system in several lineages.Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.TNF-driven cell fate: till HACE do us part.The IGF signalling pathway in Wilms tumours--a report from the ENCCA Renal Tumours Biology-driven drug development workshop.The expanding universe of hypoxia.
P2860
Q24293051-C5829815-1B42-4D80-8120-6EB4CE07A6C9Q24300797-11965B42-2BDA-4462-B912-BD19DE882A5BQ24337843-9F6B74C0-9C3D-4D23-80C7-D1090C4E50A3Q27317217-CB1DD208-544D-4860-A789-9703345B0C2DQ27318369-912EEAE2-8AF9-4C55-ADE4-DC0CB2CFA35FQ28943271-0B899DED-5570-4167-9CC1-12E1A7BB5B93Q30945124-C110F649-C851-4D62-A5FB-C0C748E73FF8Q33356416-E38EB07A-5461-4319-888D-4AFC5B323692Q33677463-25F91D69-4769-4126-BE9F-C768D9461047Q33765905-D02AE661-A6B8-4EF9-B02A-D73232F33241Q34898306-F071A138-5770-4C0B-9D6A-2D8CDEBB9CB2Q35027111-D57F4C10-AD84-4916-9850-0D5BE2A248C6Q35163343-AF15C7F7-2D29-4F2E-96E5-D8D9B8844230Q35287869-6CA651FB-43CF-43B7-A852-6BFEDB1A7D66Q36190308-505E453C-74D3-4561-B602-1A6806D65F5DQ36250061-62E0E5A8-AE35-41FB-A733-FD23BE61D8E5Q36250137-1B134043-626E-45C6-B4C3-7EEC210B2DF2Q36495194-B110472A-A793-43B2-AEE4-1831D847C324Q36881086-CBB71F61-8E67-4EC1-8871-B78C2ED7F064Q36947062-6E82254B-868C-42DC-960D-E676C161A983Q36968948-80754996-6BC5-4E35-91A8-28221FC5653DQ37330142-5A865FCE-CE36-4FAB-B0BF-580AC16482B0Q37377572-E6FA53C5-3E3A-4507-8585-89232E7430FFQ37612752-943A6A2B-1107-461C-BB1F-D2D4A6B6547CQ37641476-7F568617-DD1F-4204-8864-C20554E64BB4Q38025873-BD0EADC2-A0F3-4419-9996-06EB5B6D1CC9Q38252591-42F56AE4-4378-4B65-BD29-C07B1373C613Q38289038-A85E1A3D-51FB-4F8C-8041-AB8FFCE06B51Q38351949-F2B8F516-2765-4B22-94C4-39651FC053A4Q38606750-D0F18027-1687-43EA-A703-CD4637574ABEQ38764772-F3DFBBC8-67EA-4558-A600-E27B535BF1BAQ38933808-3BD9C3FE-9970-4CAF-B45A-E44B1B4AFF10Q39061540-4FBF2E1E-2F8A-47FA-829E-08F4C53D8E1EQ39124376-F8F9A4F0-447D-4EC5-8ECF-794E9BB5D5F2Q39273903-9F16B5F9-8357-425A-9926-D4200DEC988BQ39438764-A2F3033B-B92C-406D-97AE-184AE5BF775BQ42315389-B4E17F15-1B9A-48DA-A66F-0E91B557141AQ42333576-4B330DE0-085F-4308-9933-701059CD85FEQ42995400-42DEE8A0-EFAB-47B2-AE48-F58954F1A82FQ43079289-29740BE4-961C-4069-8725-A182ADD5E9FF
P2860
The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers
description
article
@en
im August 2007 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в серпні 2007
@uk
ലേഖനം
@ml
name
The E3 ligase HACE1 is a criti ...... r involved in multiple cancers
@en
The E3 ligase HACE1 is a criti ...... r involved in multiple cancers
@nl
type
label
The E3 ligase HACE1 is a criti ...... r involved in multiple cancers
@en
The E3 ligase HACE1 is a criti ...... r involved in multiple cancers
@nl
prefLabel
The E3 ligase HACE1 is a criti ...... r involved in multiple cancers
@en
The E3 ligase HACE1 is a criti ...... r involved in multiple cancers
@nl
P2093
P2860
P50
P356
P1433
P1476
The E3 ligase HACE1 is a criti ...... r involved in multiple cancers
@en
P2093
Hiromitsu Hara
Liyong Zhang
Mai P Nghiem
Nataliya Melnyk
Peter P Liu
Poul H Sorensen
Renu Sarao
P2860
P2888
P304
P356
10.1038/NM1621
P407
P577
2007-08-12T00:00:00Z