Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization
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The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinasePalmitoylation of endothelin receptor A. Differential modulation of signal transduction activity by post-translational modificationMultiple human D5 dopamine receptor genes: a functional receptor and two pseudogenesThe structural basis of arrestin-mediated regulation of G-protein-coupled receptorsEngineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signalingG-protein-coupled receptor kinase 2 and endothelial dysfunction: molecular insights and pathophysiological mechanismsMechanisms of altered Ca²⁺ handling in heart failureDetermination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor functionIdentification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptorC-terminal truncation of the neurokinin-2 receptor causes enhanced and sustained agonist-induced signaling. Role of receptor phosphorylation in signal attenuationIdentification of a short linear sequence present in the C-terminal tail of the rat follitropin receptor that modulates arrestin-3 binding in a phosphorylation-independent fashionThe proximal portion of the COOH terminus of the oxytocin receptor is required for coupling to g(q), but not g(i). Independent mechanisms for elevating intracellular calcium concentrations from intracellular storesComputational analysis of the CB1 carboxyl-terminus in the receptor-G protein complexCargo-mediated regulation of a rapid Rab4-dependent recycling pathwayInvolvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptorBeta-adrenergic receptors: astrocytic localization in the adult visual cortex and their relation to catecholamine axon terminals as revealed by electron microscopic immunocytochemistry.Agonist-induced endocytosis and receptor phosphorylation mediate resensitization of dopamine D(2) receptors.Protein kinase C is not necessary for peptide-induced suppression of M current or for desensitization of the peptide receptors.Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.Altered phosphorylation and desensitization patterns of a human beta 2-adrenergic receptor lacking the palmitoylated Cys341.Functional modulation of GABAB receptors by protein kinases and receptor trafficking.cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposureFour consecutive serines in the third intracellular loop are the sites for beta-adrenergic receptor kinase-mediated phosphorylation and desensitization of the alpha 2A-adrenergic receptor.Importance of regions outside the cytoplasmic tail of G-protein-coupled receptors for phosphorylation and dephosphorylation.The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes.Molecular cloning of a human beta 3-adrenergic receptor cDNA.Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail.A Pluridimensional View of Biased Agonism.Acute and chronic regulation of pituitary receptors for vasopressin and corticotropin releasing hormone.G-protein-coupled receptor phosphorylation: where, when and by whom.Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responsesAgonist-induced phosphorylation and desensitization of the P2Y2 nucleotide receptor.In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptorsG-protein linked receptors: a family probed by molecular cloning and mutagenesis procedures.Cellular signaling by an agonist-activated receptor/Gs alpha fusion protein.Role of receptor-attached phosphates in binding of visual and non-visual arrestins to G protein-coupled receptors.Expression of beta 3-adrenoceptor mRNA in rat tissues.G Protein-Coupled Receptor Kinase 2 (GRK2) and 5 (GRK5) Exhibit Selective Phosphorylation of the Neurotensin Receptor in Vitro.A serine cluster prevents recycling of the V2 vasopressin receptorReceptor sequestration in response to β-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression.
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P2860
Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в травні 1988
@uk
name
Removal of phosphorylation sit ...... onist-promoted desensitization
@en
Removal of phosphorylation sit ...... onist-promoted desensitization
@nl
type
label
Removal of phosphorylation sit ...... onist-promoted desensitization
@en
Removal of phosphorylation sit ...... onist-promoted desensitization
@nl
prefLabel
Removal of phosphorylation sit ...... onist-promoted desensitization
@en
Removal of phosphorylation sit ...... onist-promoted desensitization
@nl
P2093
P356
P1433
P1476
Removal of phosphorylation sit ...... onist-promoted desensitization
@en
P2093
Antonio De Blasi
Brian F. O'Dowd
Marc G. Caron
Robert J. Lefkowitz
William P. Hausdorff
P2888
P304
P356
10.1038/333370A0
P407
P577
1988-05-01T00:00:00Z
P5875
P6179
1027291019