Investigating the biological functions of DNA topoisomerases in eukaryotic cells
about
Cellular roles of dna topoisomerases: a molecular perspectiveModulation of human DNA topoisomerase IIalpha function by interaction with 14-3-3epsilonPhylogenomics of type II DNA topoisomerasesThe broken genome: genetic and pharmacologic approaches to breaking DNAGenome-destabilizing effects associated with top1 loss or accumulation of top1 cleavage complexes in yeastTopoisomerase IIIalpha is required for normal proliferation and telomere stability in alternative lengthening of telomeres.DNA-AP sites generation by etoposide in whole blood cells.Enforced cytokinesis without complete nuclear division in embryonic cells depleting the activity of DNA topoisomerase IIalpha.20-(S)-camptothecin analogues as DNA topoisomerase I inhibitors: a QSAR study.Lethal and mutagenic interactions between γ-rays, cisplatin and etoposide at the cellular and molecular levels.Assessing sensitivity to antibacterial topoisomerase II inhibitors.SCAN1 mutant Tdp1 accumulates the enzyme--DNA intermediate and causes camptothecin hypersensitivityThe use of divalent metal ions by type II topoisomerases.Human Tdp1 cleaves a broad spectrum of substrates, including phosphoamide linkages.Single-molecule analysis uncovers the difference between the kinetics of DNA decatenation by bacterial topoisomerases I and III.DNA topoisomerases as targets for anticancer drugs.DNA topoisomerase II as a target for cancer chemotherapy.Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1.Role of Flexibility in Protein-DNA-Drug Recognition: The Case of Asp677Gly-Val703Ile Topoisomerase Mutant Hypersensitive to Camptothecin.Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitorsNovel antitrypanosomal agents.Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan-Meier plotterGlobal Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes.Targeting of topoisomerases for prognosis and drug resistance in ovarian cancer.DNA Topology and Topoisomerases: Teaching a "Knotty" Subject.Forces and torques in the nucleus: chromatin under mechanical constraints.Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism.Positioning the 3'-DNA terminus for topoisomerase II-mediated religation.Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactions.A mutation in human topoisomerase II alpha whose expression is lethal in DNA repair-deficient yeast cells.Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I.A two-drug model for etoposide action against human topoisomerase IIalpha.2-aryl benzimidazole conjugate induced apoptosis in human breast cancer MCF-7 cells through caspase independent pathway.Topoisomerases: Resistance versus Sensitivity, How Far We Can Go?TCH-1030 targeting on topoisomerase I induces S-phase arrest, DNA fragmentation, and cell death of breast cancer cells.Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors.Synthesis and biological evaluation of novel naphthoquinone fused cyclic aminoalkylphosphonates and aminoalkylphosphonic monoester.Isolation and characterization of mAMSA-hypersensitive mutants. Cytotoxicity of Top2 covalent complexes containing DNA single strand breaksCtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1.Topoisomerase II from Chlorella virus PBCV-1 has an exceptionally high DNA cleavage activity.
P2860
Q22121990-4B10CAD1-2744-4020-BE7D-65B657ACD83EQ22254010-A9B6A3C6-34AA-48B4-9F95-4408FCF6F883Q28210906-3369F568-A5AB-4785-8378-4D0C787E011EQ28299327-21085E82-FA4E-420B-8B8E-C8F4364B40E3Q28545243-E3B1B452-F7D2-4ED9-ABDE-32F558518A3AQ30482066-25716472-1759-4996-8C6B-45DF71759FDFQ30886598-5A80CE0C-A222-445B-B237-1C9B36DC02CBQ30903327-7E9C0FEA-6AA2-4535-8543-877A340FB9C0Q33299859-46E6F0FC-6B3A-4ED2-8FC3-E005EF0E5268Q33763766-345CDF53-BDEF-4E74-A77F-0E6168961C10Q33771873-F17464E0-2EF8-49A2-98B1-6E41055D79EBQ33854172-6A95F7B7-A1F2-41F3-99A2-6F9CD46D04D7Q34054930-66358E58-8389-4C1B-B30B-EB68F30E8C8CQ34312801-2EFEBE22-A61E-4F03-89D1-83B13F1A3DFEQ34312968-F6536056-29FA-4583-BB75-06EC4FA1778FQ34448509-F5BB1ECA-01B9-4C2B-BA44-0725830F5496Q34718447-B8F73CDE-7AB5-488F-8D7D-498E26155CCBQ35152316-328D5DA7-C32E-4605-89D6-2A501782ACDDQ35724882-21CC9CF0-E037-495B-88CD-D53DC851B319Q36028611-37EC017F-BEFD-4C27-A620-66B0612F23D8Q36210891-DAF9C704-791A-4F1A-863F-B98779D1842BQ36326965-41238249-ECE8-41A3-A0E9-66C8D60EC37BQ36644164-82FDB031-565D-4E3B-9F33-DC0CE69A74A1Q37018096-E9071968-586C-406B-8715-EC0C21AED7C3Q37098901-1BAC422E-40BD-4A7F-B2F3-3D010445AF7FQ37398648-C6083D24-B92D-4014-BB65-5EEA176CC070Q38288542-18E17D99-3952-48EA-BBC6-CD93E586E732Q38300639-94E3161C-A570-4417-8D82-69379CD8E5E0Q38320285-82A6A08C-BF7D-4BD1-84E3-3AFA3E91987BQ38343316-04AFA42D-13A6-4BC7-BC1C-7BA2C83CD893Q38351710-5AD13E97-207C-459D-AB81-F3D24FCFF21CQ38359958-865EBDA0-7576-4180-9036-44332BD514B6Q38738909-A0417A69-E112-474C-A575-8B1D4CBAD06FQ38968355-57577E3C-485A-4345-AE54-061BAE692EE6Q39190645-90E15CF0-5533-4B6E-9F4B-177E48DFE51BQ39268499-4A68A6D9-FF94-4879-8E91-A9F20E97E0CAQ40100240-CA40B376-EE4C-4BBB-B382-03B3B5D0C131Q42114704-3EFB754E-1DAF-4625-B4D4-6668F7904228Q42704196-ADD25C9A-4837-4E71-B2D5-2A7DF63BC85FQ43589179-2C6402D0-8B48-4FFF-B6FB-7EAA50F039E7
P2860
Investigating the biological functions of DNA topoisomerases in eukaryotic cells
description
article
@en
im Oktober 1998 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в жовтні 1998
@uk
name
Investigating the biological functions of DNA topoisomerases in eukaryotic cells
@en
Investigating the biological functions of DNA topoisomerases in eukaryotic cells
@nl
type
label
Investigating the biological functions of DNA topoisomerases in eukaryotic cells
@en
Investigating the biological functions of DNA topoisomerases in eukaryotic cells
@nl
prefLabel
Investigating the biological functions of DNA topoisomerases in eukaryotic cells
@en
Investigating the biological functions of DNA topoisomerases in eukaryotic cells
@nl
P1476
Investigating the biological functions of DNA topoisomerases in eukaryotic cells
@en
P2093
John L. Nitiss
P356
10.1016/S0167-4781(98)00128-6
P577
1998-10-01T00:00:00Z