Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
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Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heartCaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitationIon Channels in the HeartL-type calcium channel targeting and local signalling in cardiac myocytesCalmodulin-dependent protein kinase II: linking heart failure and arrhythmiasMechanisms of altered Ca²⁺ handling in heart failureCa(2+) current facilitation is CaMKII-dependent and has arrhythmogenic consequencesNew therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII)Modal gating of human CaV2.1 (P/Q-type) calcium channels: I. The slow and the fast gating modes and their modulation by beta subunitsStimulation of recombinant Ca(v)3.2, T-type, Ca(2+) channel currents by CaMKIIgamma(C)Calmodulin kinase and a calmodulin-binding 'IQ' domain facilitate L-type Ca2+ current in rabbit ventricular myocytes by a common mechanismSimulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validationRegulation of L-type inward calcium channel activity by captopril and angiotensin II via the phosphatidyl inositol 3-kinase pathway in cardiomyocytes from volume-overload hypertrophied rat heartsCaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylationThe ß subunit of voltage-gated Ca2+ channelsCalmodulin binding proteins provide domains of local Ca2+ signaling in cardiac myocytesSynergy between CaMKII substrates and β-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.Molecular basis for the modulation of native T-type Ca2+ channels in vivo by Ca2+/calmodulin-dependent protein kinase II.Differential control of calcium homeostasis and vascular reactivity by Ca2+/calmodulin-dependent kinase II.Acidosis and ischemia increase cellular Ca2+ transient alternans and repolarization alternans susceptibility in the intact rat heart.Regulation of excitation-contraction coupling in mouse cardiac myocytes: integrative analysis with mathematical modellingInhibition of pancreatic β-cell Ca2+/calmodulin-dependent protein kinase II reduces glucose-stimulated calcium influx and insulin secretion, impairing glucose tolerance.Dynamic alterations in the CaV1.2/CaM/CaMKII signaling pathway in the left ventricular myocardium of ischemic rat heartsNa+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytesProtein Kinases as Drug Development Targets for Heart Disease TherapyA coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.CaV1.2 beta-subunit coordinates CaMKII-triggered cardiomyocyte death and afterdepolarizationsToward a hierarchy of mechanisms in CaMKII-mediated arrhythmia.There goes the neighborhood: pathological alterations in T-tubule morphology and consequences for cardiomyocyte Ca2+ handling.alpha1-adrenoceptor stimulation potentiates L-type Ca2+ current through Ca2+/calmodulin-dependent PK II (CaMKII) activation in rat ventricular myocytes.Facilitation of murine cardiac L-type Ca(v)1.2 channel is modulated by calmodulin kinase II-dependent phosphorylation of S1512 and S1570The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizationsModeling the actions of beta-adrenergic signaling on excitation--contraction coupling processesDecoding calcium signals involved in cardiac growth and function.Dedicated myosin light chain kinases with diverse cellular functions.Role of CaMKII in RyR leak, EC coupling and action potential duration: a computational model.Ion channel remodeling in gastrointestinal inflammationCa2+-calmodulin-dependent protein kinase II potentiates store-operated Ca2+ currentThe L-type calcium channel in the heart: the beat goes onRegulation of voltage-gated Ca(2+) currents by Ca(2+)/calmodulin-dependent protein kinase II in resting sensory neurons.
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Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
description
im März 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 01 March 2000
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в березні 2000
@uk
name
Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
@en
Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
@nl
type
label
Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
@en
Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
@nl
prefLabel
Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
@en
Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
@nl
P2093
P2860
P356
P1433
P1476
Calmodulin kinase determines calcium-dependent facilitation of L-type calcium channels
@en
P2093
P2860
P2888
P304
P356
10.1038/35004052
P407
P577
2000-03-01T00:00:00Z