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Identification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatBComplementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain InhibitorsQuantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase InhibitorsAn artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activitiesDiscovery of Novel Liver-Stage Antimalarials through Quantum SimilaritySelective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory siteHigh-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinationsHigh-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol proteaseComparison of bioluminescent kinase assays using substrate depletion and product formation.Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)Biochemical assays for the discovery of TDP1 inhibitorsHigh-throughput screen identifies cyclic nucleotide analogs that inhibit prostatic acid phosphatase.A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1Artemisinin-derived dimer diphenyl phosphate is an irreversible inhibitor of human cytomegalovirus replication.A furoxan-amodiaquine hybrid as a potential therapeutic for three parasitic diseases().Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung CancerArtemisinin-derived dimer ART-838 potently inhibited human acute leukemias, persisted in vivo, and synergized with antileukemic drugs.Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse CompoundsmQC: A Heuristic Quality-Control Metric for High-Throughput Drug Combination Screening.In vitro screening of compounds against laboratory and field isolates of human hookworm reveals quantitative differences in anthelmintic susceptibility.Personalized medicine: changing the paradigm of drug development.Synthesis and antimalarial efficacy of two-carbon-linked, artemisinin-derived trioxane dimers in combination with known antimalarial drugs.Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine.Unique and highly selective anticytomegalovirus activities of artemisinin-derived dimer diphenyl phosphate stem from combination of dimer unit and a diphenyl phosphate moiety.The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial drug artemether.
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Bryan T Mott
@ast
Bryan T Mott
@en
Bryan T Mott
@es
Bryan T Mott
@nl
type
label
Bryan T Mott
@ast
Bryan T Mott
@en
Bryan T Mott
@es
Bryan T Mott
@nl
prefLabel
Bryan T Mott
@ast
Bryan T Mott
@en
Bryan T Mott
@es
Bryan T Mott
@nl
P106
P1153
24779772600
P31
P496
0000-0002-1912-6362