Negative regulation of NOTCH4 signaling - Wikidata - wikimedia - TriplyDB

Negative regulation of NOTCH4 signaling

Negative regulation of NOTCH4 signaling

http://www.wikidata.org/entity/Q56861027

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AKT1 phosphorylates NOTCH4 p-4S-NICD4 binds YWHAZ Unknown kinase phosphorylates NICD4 FBXW7 promotes ubiquitination of p-NICD4 Proteasome degrades ubiquitinated NICD4 NICD4 binds to TACC3

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Negative regulation of NOTCH4 signaling

http://www.wikidata.org/entity/Q56861027

description

An instance of the biological ...... TCH4 signaling in Homo sapiens

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name

Negative regulation of NOTCH4 signaling

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type

label

Negative regulation of NOTCH4 signaling

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prefLabel

Negative regulation of NOTCH4 signaling

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SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats

Trp53 regulates Notch 4 signaling through Mdm2.

Elongin C is a mediator of Notch4 activity in human renal tubule cells.

AKT and 14-3-3 regulate Notch4 nuclear localization.

Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

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reactome:R-HSA-9604323

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negative regulation of Notch signaling pathway

biological pathway

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R-HSA-9604323

http://www.w3.org/2001/XMLSchema#string

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AKT1 phosphorylates NOTCH4

p-4S-NICD4 binds YWHAZ

Unknown kinase phosphorylates NICD4

FBXW7 promotes ubiquitination of p-NICD4

Proteasome degrades ubiquitinated NICD4

NICD4 binds to TACC3

P703