CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction
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CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanismsModulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptorsEngagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activationA bispecific protein capable of engaging CTLA-4 and MHCII protects non-obese diabetic mice from autoimmune diabetesTargeting CD28, CTLA-4 and PD-L1 costimulation differentially controls immune synapses and function of human regulatory and conventional T-cellsRegulatory T cells phenotype in different clinical forms of Chagas' diseaseInterleukin-4-independent acceleration of cutaneous leishmaniasis in susceptible BALB/c mice following treatment with anti-CTLA4 antibody.CTLA-4 down-regulates the protective anticryptococcal cell-mediated immune responseCytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tailInteraction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation.Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses.Ligation of cytotoxic T lymphocyte antigen-4 to T cell receptor inhibits T cell activation and directs differentiation into Foxp3+ regulatory T cellsFas-independent death of activated CD4(+) T lymphocytes induced by CTLA-4 crosslinking.Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25.Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activationModulation of susceptibility to HIV-1 infection by the cytotoxic T lymphocyte antigen 4 costimulatory molecule.Checkpoint blockade in cancer immunotherapyOX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival.Alterations of the expression of T-cell-related costimulatory CD28 and downregulatory CD152 (CTLA-4) molecules in patients with B-cell chronic lymphocytic leukaemia.At the bench: preclinical rationale for CTLA-4 and PD-1 blockade as cancer immunotherapyShifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.Impaired function of CTLA-4 in the lungs of patients with chronic beryllium disease contributes to persistent inflammation.PD-1 signaling in primary T cellsCD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function.CD3 hyporesponsiveness and in vitro apoptosis are features of T cells from both malignant and nonmalignant secondary lymphoid organs.Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.CTLA-4-Tg/CD-28-KO Mice Exhibit Reduced T Cell Proliferation in vivo Compared to CD-28-KO Mice in a Graft-versus-host Disease Model.Cdc18 transcription and proteolysis couple S phase to passage through mitosisDisparate effects of phorbol esters, CD3 and the costimulatory receptors CD2 and CD28 on RANTES secretion by human T lymphocytesStimulation of a shorter duration in the state of anergy by an invariant natural killer T cell agonist enhances its efficiency of protection from type 1 diabetes
P2860
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P2860
CTLA-4 ligation delivers a unique signal to resting human CD4 T cells that inhibits interleukin-2 secretion but allows Bcl-X(L) induction
description
im Januar 1998 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 01 January 1998
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в січні 1998
@uk
name
CTLA-4 ligation delivers a uni ...... n-2 secretion but allows Bcl-X
@nl
CTLA-4 ligation delivers a uni ...... but allows Bcl-X(L) induction
@en
type
label
CTLA-4 ligation delivers a uni ...... n-2 secretion but allows Bcl-X
@nl
CTLA-4 ligation delivers a uni ...... but allows Bcl-X(L) induction
@en
prefLabel
CTLA-4 ligation delivers a uni ...... n-2 secretion but allows Bcl-X
@nl
CTLA-4 ligation delivers a uni ...... but allows Bcl-X(L) induction
@en
P2093
P1476
CTLA-4 ligation delivers a uni ...... but allows Bcl-X(L) induction
@en
P2093
B L Levine
B M Carreno
N Craighead
S J Perfetto
T Francomano
P407
P577
1998-01-01T00:00:00Z