about
Genome stability is ensured by temporal control of kinetochore-microtubule dynamicsChromosomal instability and cancer: a complex relationship with therapeutic potentialDynactin is required for microtubule anchoring at centrosomesThe kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.Regulation of kinetochore-microtubule attachments through homeostatic control during mitosisEfficient mitosis in human cells lacking poleward microtubule fluxLGN blocks the ability of NuMA to bind and stabilize microtubules. A mechanism for mitotic spindle assembly regulation.The mitotic origin of chromosomal instability.Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux.Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastropheInterplay of microtubule dynamics and sliding during bipolar spindle formation in mammalian cellsProliferation of aneuploid human cells is limited by a p53-dependent mechanism.A mechanistic model for the organization of microtubule asters by motor and non-motor proteins in a mammalian mitotic extract.New tools for the antimitotic toolbox.Spindle assembly in animal cells.STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments.DNA-damage response during mitosis induces whole-chromosome missegregationSearching for the middle ground: mechanisms of chromosome alignment during mitosis.Anaphase catastrophe is a target for cancer therapySpindle pole mechanics studied in mitotic asters: dynamic distribution of spindle forces through compliant linkages.Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors.Chromosomal instability substantiates poor prognosis in patients with diffuse large B-cell lymphoma.Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.Mitosis: PARty time in the spindle.Mitotic spindle poles are organized by structural and motor proteins in addition to centrosomes.Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachmentsMinus-end capture of preformed kinetochore fibers contributes to spindle morphogenesis.NuMA is required for the proper completion of mitosis.Structural and regulatory roles of nonmotor spindle proteinsA double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instabilityChromosomes and cancer cells.Mechanisms of chromosomal instability.Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.Deviant kinetochore microtubule dynamics underlie chromosomal instability.SnapShot: Nonmotor proteins in spindle assembly.Cancer: CINful centrosomes.Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation.Multiple mechanisms regulate NuMA dynamics at spindle poles.NuMA, a nuclear protein involved in mitosis and nuclear reformation.NuMA is required for the organization of microtubules into aster-like mitotic arrays.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Duane A Compton
@ast
Duane A Compton
@en
Duane A Compton
@es
Duane A Compton
@nl
type
label
Duane A Compton
@ast
Duane A Compton
@en
Duane A Compton
@es
Duane A Compton
@nl
prefLabel
Duane A Compton
@ast
Duane A Compton
@en
Duane A Compton
@es
Duane A Compton
@nl
P106
P1153
35546021600
P31
P496
0000-0002-4445-9118