about
Validation and development of MTH1 inhibitors for treatment of cancer.Neurotoxicity and low paclitaxel clearance associated with concomitant clopidogrel therapy in a 60-year-old Caucasian woman with ovarian carcinomaRole of Cytochrome P450 2C8 in Drug Metabolism and Interactions.Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates.Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast.Autoinhibition of CYP3A4 leads to important role of CYP2C8 in imatinib metabolism: variability in CYP2C8 activity may alter plasma concentrations and response.Gemfibrozil impairs imatinib absorption and inhibits the CYP2C8-mediated formation of its main metabolite.Clopidogrel Carboxylic Acid Glucuronidation is Mediated Mainly by UGT2B7, UGT2B4, and UGT2B17: Implications for Pharmacogenetics and Drug-Drug Interactions .In vitro assessment of time-dependent inhibitory effects on CYP2C8 and CYP3A activity by fourteen protein kinase inhibitors.Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug–Drug InteractionsReevaluation of the Microsomal Metabolism of Montelukast: Major Contribution by CYP2C8 at Clinically Relevant ConcentrationsImproved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrationsCritical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Anne M Filppula
@ast
Anne M Filppula
@en
Anne M Filppula
@es
Anne M Filppula
@nl
type
label
Anne M Filppula
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Anne M Filppula
@en
Anne M Filppula
@es
Anne M Filppula
@nl
prefLabel
Anne M Filppula
@ast
Anne M Filppula
@en
Anne M Filppula
@es
Anne M Filppula
@nl
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P496
0000-0002-7932-8265