about
Synthesis and biological activity of human neuropeptide S analogues modified in position 5: identification of potent and pure neuropeptide S receptor antagonistsIn vitro and in vivo pharmacological characterization of the neuropeptide s receptor antagonist [D-Cys(tBu)5]neuropeptide SNeuropeptide S is a stimulatory anxiolytic agent: a behavioural study in miceSolution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domainThe tachykinin peptide familyInteraction of sweet proteins with their receptor. A conformational study of peptides corresponding to loops of brazzein, monellin and thaumatinThe effects of neuropeptide S on general anesthesia in ratsThe SH3 domain of nebulin binds selectively to type II peptides: theoretical prediction and experimental validation.Pain peptides. Solution structure of orphanin FQ2.Nociceptin/orphanin FQ receptor ligands.Solution structure of amyloid beta-peptide (25-35) in different media.Characterization of the locomotor activity-inhibiting effect of nociceptin/orphanin FQ in mice.6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides.What peptides these deltorphins be.Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic.Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds.Evolution of the Bifunctional Lead μ Agonist / δ Antagonist Containing the Dmt-Tic Opioid PharmacophoreStructure-activity relationships of nociceptin and related peptides: comparison with dynorphin A.Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compoundsNew 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligandsNonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: design, synthesis and in vitro pharmacological activity.Blockade of nociceptin/orphanin FQ receptor signaling in rat substantia nigra pars reticulata stimulates nigrostriatal dopaminergic transmission and motor behavior.Conformational properties of deltorphin: new features of the delta-opioid receptor.Structure-activity studies on neuropeptide S: identification of the amino acid residues crucial for receptor activation.Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic.In vitro and in vivo pharmacological characterization of nociceptin/orphanin FQ tetrabranched derivatives.Pharmacological profile of nociceptin/orphanin FQ receptors.δ-Opioid receptor activation modified microRNA expression in the rat kidney under prolonged hypoxia.Synthesis and biological activity of human neuropeptide S analogues modified in position 2.Structure-activity study at positions 3 and 4 of human neuropeptide S.Solution structure of nociceptin peptides.Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).In vitro and in vivo pharmacological characterization of the novel UT receptor ligand [Pen5,DTrp7,Dab8]urotensin II(4-11) (UFP-803)Dmt and opioid peptides: a potent alliance.Antagonism in opioid peptides: the role of conformation.In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptorHydrogen sulfide induced disruption of Na+ homeostasis in the cortex.A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-TicIn vitro and in vivo pharmacological profile of UFP-512, a novel selective delta-opioid receptor agonist; correlations between desensitization and tolerance.[Dmt1]N/OFQ(1-13)-NH2: a potent nociceptin/orphanin FQ and opioid receptor universal agonist.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Severo Salvadori
@ast
Severo Salvadori
@en
Severo Salvadori
@es
Severo Salvadori
@nl
type
label
Severo Salvadori
@ast
Severo Salvadori
@en
Severo Salvadori
@es
Severo Salvadori
@nl
prefLabel
Severo Salvadori
@ast
Severo Salvadori
@en
Severo Salvadori
@es
Severo Salvadori
@nl
P106
P1153
7005648916
P31
P496
0000-0002-8224-2358