Down-Modulation of CD8 β-Chain in Response to an Altered Peptide Ligand Enables Developing Thymocytes to Escape Negative Selection
about
Restricted autoantigen recognition associated with deletional and adaptive regulatory mechanisms.A constant affinity threshold for T cell tolerance.Selection of self-reactive T cells in the thymus.Thymic differentiation of TCR alpha beta(+) CD8 alpha alpha(+) IELs.An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells.An optimized CD4 T-cell response can control productive and latent gammaherpesvirus infectionAcute primary infection with cytomegalovirus (CMV) in kidney transplant recipients results in the appearance of a phenotypically aberrant CD8+ T cell population.Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells.
P2860
Q30492902-4023AF3F-4DA1-4041-A12E-9A89CB8670B7Q36229099-77306D81-16E2-41A1-9EC8-29103E02304FQ36456282-87D8F8DF-169F-4DAC-B2AF-57B43B16A9B7Q36732693-2506E87E-F1EF-4370-82D2-3EDBDCFCC5A5Q37394279-39274274-3B20-48AE-B6A2-330A75CA6B9BQ40909600-00FD5042-8A26-4026-B2B2-195CC95FC674Q43472510-C6090CDE-89EB-46BA-ABD0-F0643AF0D59FQ47631646-90742C6B-94E4-4C74-96BB-819602D467E1
P2860
Down-Modulation of CD8 β-Chain in Response to an Altered Peptide Ligand Enables Developing Thymocytes to Escape Negative Selection
description
article
@en
im Februar 1997 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в лютому 1997
@uk
name
Down-Modulation of CD8 β-Chain ...... s to Escape Negative Selection
@en
Down-Modulation of CD8 β-Chain ...... s to Escape Negative Selection
@nl
type
label
Down-Modulation of CD8 β-Chain ...... s to Escape Negative Selection
@en
Down-Modulation of CD8 β-Chain ...... s to Escape Negative Selection
@nl
prefLabel
Down-Modulation of CD8 β-Chain ...... s to Escape Negative Selection
@en
Down-Modulation of CD8 β-Chain ...... s to Escape Negative Selection
@nl
P2093
P356
P1433
P1476
Down-Modulation of CD8 β-Chain ...... s to Escape Negative Selection
@en
P2093
Francis R. Carbone
Megan J. Barnden
William R. Heath
P304
P356
10.1006/CIMM.1996.1054
P577
1997-02-01T00:00:00Z