Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage
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Regulation of AU-Rich Element RNA Binding Proteins by Phosphorylation and the Prolyl Isomerase Pin1Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemiaDevelopmental expression of Magmas in murine tissues and its co-expression with the GM-CSF receptorObesity-driven disruption of haematopoiesis and the bone marrow niche.Myeloproliferative disorder and leukaemia in mice induced by different classes of constitutive mutants of the human IL-3/IL-5/GM-CSF receptor common beta subunit.Regulation of macrophage-specific gene expression by degenerated lipoproteins.Pulmonary alveolar proteinosis: progress in the first 44 years.Granulocyte-macrophage colony-stimulating factor: not just another haematopoietic growth factor.TNF alpha, IL-1 alpha and bFGF are implicated in the complex disease of GM-CSF transgenic mice.The role of VEGF in normal and neoplastic hematopoiesis.The closely related CD103+ dendritic cells (DCs) and lymphoid-resident CD8+ DCs differ in their inflammatory functionsExpression of cytokines by recombinant vaccinia viruses: a model for studying cytokines in virus infections in vivo.Leukemic cells and the cytokine patchwork.Reversing the autoimmune condition: experience with experimental autoimmune gastritis.Cytokines in the differentiation therapy of leukemia: from laboratory investigations to clinical applications.Changes in chromatin accessibility across the GM-CSF promoter upon T cell activation are dependent on nuclear factor kappaB proteins.Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines.Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos.Paradoxical role of alveolar macrophage-derived granulocyte-macrophage colony-stimulating factor in pulmonary host defense post-bone marrow transplantation.Cell death in the neighbourhood: direct microenvironmental effects of apoptosis in normal and neoplastic tissues.Cytokines of the lung.The consequences of excess levels of haemopoietic growth factors.Early clinical trials with colony-stimulating factors.Determinants of eosinophil survival and apoptotic cell death.GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential.Oncogenes: past, present and future.Novel GM-CSF-based vaccines: One small step in GM-CSF gene optimization, one giant leap for human vaccines.Interleukins: from purified proteins to chains, circles, cascades and other complexities.Dysregulation of growth factor-receptor system in cellular transformation.Hemopoietic growth and inhibitory factors in treatment of malignancies. A review.Cytokine-induced changes in the leukon.Extramedullary acute promyelocytic leukemia.Preferential production of interleukin-1 beta over interleukin-1 receptor antagonist contributes to proliferation and suppression of apoptosis in leukemic cells.GM-CSF increases AP-1 DNA binding and Ref-1 amounts in human alveolar macrophages.Immunotherapeutic effects of recombinant adenovirus encoding granulocyte-macrophage colony-stimulating factor in experimental pulmonary tuberculosis.Granulocyte-macrophage colony-stimulating factor and tumor necrosis factor alpha in patients with human immunodeficiency virus (HIV) type 1 infection.Safety of a GM-CSF adjuvant-plasmid DNA malaria vaccine.Fertility impairment in granulocyte-macrophage colony-stimulating factor-deficient mice.Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells.Immune responses of IL-5 transgenic mice to parasites and aeroallergens.
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P2860
Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage
description
article
@en
im November 1987 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в листопаді 1987
@uk
name
Transgenic mice expressing a h ...... atal syndrome of tissue damage
@en
Transgenic mice expressing a h ...... atal syndrome of tissue damage
@nl
type
label
Transgenic mice expressing a h ...... atal syndrome of tissue damage
@en
Transgenic mice expressing a h ...... atal syndrome of tissue damage
@nl
prefLabel
Transgenic mice expressing a h ...... atal syndrome of tissue damage
@en
Transgenic mice expressing a h ...... atal syndrome of tissue damage
@nl
P2093
P1433
P1476
Transgenic mice expressing a h ...... atal syndrome of tissue damage
@en
P2093
D J Williamson
G K Klintworth
G Kannourakis
R A Cuthbertson
P304
P356
10.1016/0092-8674(87)90136-X
P407
P50
P577
1987-11-01T00:00:00Z