Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines. - Wikidata - wikimedia - TriplyDB

Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines.

Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines.

http://www.wikidata.org/entity/Q36400929

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Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases Leukemia-associated, constitutively active mutants of SHP2 protein tyrosine phosphatase inhibit NF1 transcriptional activation by the interferon consensus sequence binding protein Mouse models of neurofibromatosis 1 and 2.Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation Neurofibromatosis type 1 - a model for nervous system tumour formation?PU.1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in differentiating myeloid cells The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1 Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans.Mast cells and the neurofibroma microenvironment Neurofibromatosis type 1: II. Answers from animal models.Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase.Neurofibromin (Nf1) is required for skeletal muscle development Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke.Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibroma Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-γ signaling.Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells.A novel cytokine pathway suppresses glial cell melanogenesis after injury to adult nerve.PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase.Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice Genetics of neurofibromatosis 1-associated peripheral nerve sheath tumors.Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner.Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor.Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells.Continuous in vivo infusion of interferon-gamma (IFN-gamma) enhances engraftment of syngeneic wild-type cells in Fanca-/- and Fancg-/- mice Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor.Quantitative effects of Nf1 inactivation on in vivo hematopoiesis Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential.Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice.Nf1 mutant mice with p19ARF gene loss develop accelerated hematopoietic disease resembling acute leukemia with a variable phenotype.Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos.Plexiform neurofibroma genesis: questions of Nf1 gene dose and hyperactive mast cells Signaling of c-kit in dendritic cells influences adaptive immunity.Emerging functions of c-kit and its ligand stem cell factor in dendritic cells: regulators of T cell differentiation Pathogenesis of plexiform neurofibroma: tumor-stromal/hematopoietic interactions in tumor progression.

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Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines.

http://www.wikidata.org/entity/Q36400929

description

1998 nî lūn-bûn

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1998年の論文

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年學術文章

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1998年學術文章

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1998年學術文章

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name

Nf1 regulates hematopoietic pr ...... esponse to multiple cytokines.

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Nf1 regulates hematopoietic pr ...... esponse to multiple cytokines.

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type

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Nf1 regulates hematopoietic pr ...... esponse to multiple cytokines.

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Nf1 regulates hematopoietic pr ...... esponse to multiple cytokines.

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prefLabel

Nf1 regulates hematopoietic pr ...... esponse to multiple cytokines.

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Nf1 regulates hematopoietic pr ...... esponse to multiple cytokines.

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Nf1 regulates hematopoietic pr ...... esponse to multiple cytokines.

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T A Vik

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P2860

Primary structure and functional expression of rat and human stem cell factor DNAs

Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors

p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells

Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras

The GTPase superfamily: conserved structure and molecular mechanism

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins

Proteins regulating Ras and its relatives

The neurofibromatosis type 1 gene encodes a protein related to GAP

The GTPase superfamily: a conserved switch for diverse cell functions

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