Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape
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Immune cell promotion of metastasisImmune regulation of bone metastasisBone specific immunity and its impact on metastasisTargeting tumor-stromal interactions in bone metastasisOsteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche.Tumor cell dormancyMetastatic colonization by circulating tumour cellsGenetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progressionStructural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1Citrate synthase expression affects tumor phenotype and drug resistance in human ovarian carcinomaInterferon-ε protects the female reproductive tract from viral and bacterial infectionBone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapiesUSP18 is crucial for IFN-γ-mediated inhibition of B16 melanoma tumorigenesis and antitumor immunity.IRF7 in the Australian black flying fox, Pteropus alecto: evidence for a unique expression pattern and functional conservationSystematic analysis of metastasis-associated genes identifies miR-17-5p as a metastatic suppressor of basal-like breast cancer.Global transcriptome-wide analysis of CIK cells identify distinct roles of IL-2 and IL-15 in acquisition of cytotoxic capacity against tumor.An interferon signature identified by RNA-sequencing of mammary tissues varies across the estrous cycle and is predictive of metastasis-free survivalA computational model to predict bone metastasis in breast cancer by integrating the dysregulated pathways.The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo.Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance.Interferon regulatory factor 7 protects against vascular smooth muscle cell proliferation and neointima formation.Bone-immune cell crosstalk: bone diseases.Neutrophil/Lymphocyte ratio has no predictive or prognostic value in breast cancer patients undergoing preoperative systemic therapy.CD24 Overexpression Is Associated with Poor Prognosis in Luminal A and Triple-Negative Breast Cancer.IFNAR1 is a predictor for overall survival in colorectal cancer and its mRNA expression correlated with IRF7 but not TLR9Bone metastasis and the metastatic niche.Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancerBcl6 Sets a Threshold for Antiviral Signaling by Restraining IRF7 Transcriptional ProgramImmunomodulation via Chemotherapy and Targeted Therapy: A New Paradigm in Breast Cancer Therapy?Biological role of NK cells and immunotherapeutic approaches in breast cancer.Natural killer cells in non-hematopoietic malignanciesInterferome v2.0: an updated database of annotated interferon-regulated genes.Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3(+) regulatory T cells and are associated with poor prognosis in breast cancer patients.The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferonTumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis.Tumor cell dissemination: emerging biological insights from animal models and cancer patients.Selectively targeting the toll-like receptor 9 (TLR9)--IRF 7 signaling pathway by polymer blend particlesThe immune system and inflammation in breast cancer.Usp18 deficient mammary epithelial cells create an antitumour environment driven by hypersensitivity to IFN-λ and elevated secretion of Cxcl10The host STING pathway at the interface of cancer and immunity
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Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape
description
im Juli 2012 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published on 22 July 2012
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в липні 2012
@uk
name
Silencing of Irf7 pathways in ...... tastasis through immune escape
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Silencing of Irf7 pathways in ...... tastasis through immune escape
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type
label
Silencing of Irf7 pathways in ...... tastasis through immune escape
@en
Silencing of Irf7 pathways in ...... tastasis through immune escape
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prefLabel
Silencing of Irf7 pathways in ...... tastasis through immune escape
@en
Silencing of Irf7 pathways in ...... tastasis through immune escape
@nl
P2093
P2860
P50
P356
P1433
P1476
Silencing of Irf7 pathways in ...... tastasis through immune escape
@en
P2093
Andreas Möller
Bradley N Bidwell
Clare Y Slaney
Jodee Gould
Nimali P Withana
Pedram Argani
P2860
P2888
P304
P356
10.1038/NM.2830
P407
P50
P577
2012-07-22T00:00:00Z