The thiosemicarbazone MeNNMe induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition

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The thiosemicarbazone MeNNMe induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition

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http://www.wikidata.org/entity/Q57461787

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im Oktober 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 15 October 2018

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wetenschappelijk artikel

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наукова стаття, опублікована в жовтні 2018

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name

The thiosemicarbazone MeNNMe i ...... disulfide isomerase inhibition

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The thiosemicarbazone MeNNMe i ...... disulfide isomerase inhibition

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Item

label

The thiosemicarbazone MeNNMe i ...... disulfide isomerase inhibition

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The thiosemicarbazone MeNNMe i ...... disulfide isomerase inhibition

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prefLabel

The thiosemicarbazone MeNNMe i ...... disulfide isomerase inhibition

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The thiosemicarbazone MeNNMe i ...... disulfide isomerase inhibition

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P1476

The thiosemicarbazone Me2NNMe2 ...... disulfide isomerase inhibition

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Bernhard K Keppler

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Christian R Kowol

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Christine Pirker

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Gergely Szakács

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Johannes Grillari

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Karin Nowikovsky

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Katharina Korbula

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Magdalena Lang

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Petra Heffeter

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P2860

The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells

An alternative, nonapoptotic form of programmed cell death

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis

limma powers differential expression analyses for RNA-sequencing and microarray studies

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

Pathview: an R/Bioconductor package for pathway-based data integration and visualization.

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins.

Distinct mechanisms of cell-kill by triapine and its terminally dimethylated derivative Dp44mT due to a loss or gain of activity of their copper(II) complexes.

Release of Ca2+ from the endoplasmic reticulum and its subsequent influx into mitochondria trigger celastrol-induced paraptosis in cancer cells.

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1052

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scholarly article

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10.1038/S41419-018-1102-Z

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English

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2018-10-15T00:00:00Z

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30323190

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immunology

cancer research

cell biology

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6189190

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