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Functionalised staple linkages for modulating the cellular activity of stapled peptides

Functionalised staple linkages for modulating the cellular activity of stapled peptides

http://www.wikidata.org/entity/Q57540612

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Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides Oxidative diversification of amino acids and peptides by small-molecule iron catalysis Azide-rich peptides via an on-resin diazotransfer reaction.Phage-displayed macrocyclic glycopeptide libraries.Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation A New Methodology for Incorporating Chiral Linkers into Stapled Peptides.Acetone-Linked Peptides: A Convergent Approach for Peptide Macrocyclization and Labeling.The future perspectives of natural materials for pulmonary drug delivery and lung tissue engineering.Modulating protein-protein interactions: the potential of peptides.An enhanced functional interrogation/manipulation of intracellular signaling pathways with the peptide 'stapling' technology.Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.Bioconjugation - using selective chemistry to enhance the properties of proteins and peptides as therapeutics and carriers.Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides.Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity.Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.Receptor-templated stapling of intrinsically disordered peptide ligands.Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling.Hydrocarbon constrained peptides - understanding preorganisation and binding affinity.Double quick, double click reversible peptide "stapling".Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation.Investigating peptide sequence variations for 'double-click' stapled p53 peptides.An in-tether chiral center modulates the proapoptotic activity of the KLA peptide.Effect of Stapling Architecture on Physiochemical Properties and Cell Permeability of Stapled α-Helical Peptides: A Comparative Study.Peptide Macrocycles Developed from Precisely Regulated Multiple Cyclization of Unprotected Peptides.Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.Locking Interconversion of Aromatic Oligoamide Foldamers by Intramolecular Side-chain Crosslinking: toward Absolute Control of Helicity in Synthetic Aromatic Foldamers.Stabilization of peptides against proteolysis through disulfide-bridged conjugation with synthetic aromatics.Diversity-Oriented Peptide Stapling: A Third Generation Copper-Catalysed Azide-Alkyne Cycloaddition Stapling and Functionalisation Strategy.Application of Thiol-yne/Thiol-ene Reactions for Peptide and Protein Macrocyclizations.Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides.A two-component 'double-click' approach to peptide stapling.Crosslinked Aspartic Acids as Helix-Nucleating Templates.An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide.Improving cell penetration of helical peptides stabilized by N-terminal crosslinked aspartic acids.Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions.A proline-derived transannular N-cap for nucleation of short α-helical peptides.Stapling of unprotected helical peptides via photo-induced intramolecular thiol-yne hydrothiolation.Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer

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P2860

Functionalised staple linkages for modulating the cellular activity of stapled peptides

http://www.wikidata.org/entity/Q57540612

description

article

@en

im Januar 2014 veröffentlichter wissenschaftlicher Artikel

@de

wetenschappelijk artikel

@nl

наукова стаття, опублікована у 2014

@uk

name

Functionalised staple linkages for modulating the cellular activity of stapled peptides

@en

Functionalised staple linkages for modulating the cellular activity of stapled peptides

@nl

type

label

Functionalised staple linkages for modulating the cellular activity of stapled peptides

@en

Functionalised staple linkages for modulating the cellular activity of stapled peptides

@nl

prefLabel

Functionalised staple linkages for modulating the cellular activity of stapled peptides

@en

Functionalised staple linkages for modulating the cellular activity of stapled peptides

@nl

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P1433

Chemical Science

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Functionalised staple linkages for modulating the cellular activity of stapled peptides

@en

P2093

Ashok R. Venkitaraman

http://www.w3.org/2001/XMLSchema#string

Chandra Verma

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Christopher J. Brown

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David P. Lane

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David R. Spring

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Laura S. Itzhaki

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Luca Laraia

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Marko Hyvönen

http://www.w3.org/2001/XMLSchema#string

Niklas Sköld

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Pamela J. E. Rowling

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1804-1809

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scholarly article

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10.1039/C4SC00045E

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5

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5

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2014-01-01T00:00:00Z

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