Functionalised staple linkages for modulating the cellular activity of stapled peptides
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Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled PeptidesOxidative diversification of amino acids and peptides by small-molecule iron catalysisAzide-rich peptides via an on-resin diazotransfer reaction.Phage-displayed macrocyclic glycopeptide libraries.Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-AlkylationA New Methodology for Incorporating Chiral Linkers into Stapled Peptides.Acetone-Linked Peptides: A Convergent Approach for Peptide Macrocyclization and Labeling.The future perspectives of natural materials for pulmonary drug delivery and lung tissue engineering.Modulating protein-protein interactions: the potential of peptides.An enhanced functional interrogation/manipulation of intracellular signaling pathways with the peptide 'stapling' technology.Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.Bioconjugation - using selective chemistry to enhance the properties of proteins and peptides as therapeutics and carriers.Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides.Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity.Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer.Receptor-templated stapling of intrinsically disordered peptide ligands.Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling.Hydrocarbon constrained peptides - understanding preorganisation and binding affinity.Double quick, double click reversible peptide "stapling".Divergent unprotected peptide macrocyclisation by palladium-mediated cysteine arylation.Investigating peptide sequence variations for 'double-click' stapled p53 peptides.An in-tether chiral center modulates the proapoptotic activity of the KLA peptide.Effect of Stapling Architecture on Physiochemical Properties and Cell Permeability of Stapled α-Helical Peptides: A Comparative Study.Peptide Macrocycles Developed from Precisely Regulated Multiple Cyclization of Unprotected Peptides.Targeting the Genome-Stability Hub Ctf4 by Stapled-Peptide Design.Locking Interconversion of Aromatic Oligoamide Foldamers by Intramolecular Side-chain Crosslinking: toward Absolute Control of Helicity in Synthetic Aromatic Foldamers.Stabilization of peptides against proteolysis through disulfide-bridged conjugation with synthetic aromatics.Diversity-Oriented Peptide Stapling: A Third Generation Copper-Catalysed Azide-Alkyne Cycloaddition Stapling and Functionalisation Strategy.Application of Thiol-yne/Thiol-ene Reactions for Peptide and Protein Macrocyclizations.Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides.A two-component 'double-click' approach to peptide stapling.Crosslinked Aspartic Acids as Helix-Nucleating Templates.An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide.Improving cell penetration of helical peptides stabilized by N-terminal crosslinked aspartic acids.Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions.A proline-derived transannular N-cap for nucleation of short α-helical peptides.Stapling of unprotected helical peptides via photo-induced intramolecular thiol-yne hydrothiolation.Development of Cell-Permeable, Non-Helical Constrained Peptides to Target a Key Protein-Protein Interaction in Ovarian Cancer
P2860
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P2860
Functionalised staple linkages for modulating the cellular activity of stapled peptides
description
article
@en
im Januar 2014 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована у 2014
@uk
name
Functionalised staple linkages for modulating the cellular activity of stapled peptides
@en
Functionalised staple linkages for modulating the cellular activity of stapled peptides
@nl
type
label
Functionalised staple linkages for modulating the cellular activity of stapled peptides
@en
Functionalised staple linkages for modulating the cellular activity of stapled peptides
@nl
prefLabel
Functionalised staple linkages for modulating the cellular activity of stapled peptides
@en
Functionalised staple linkages for modulating the cellular activity of stapled peptides
@nl
P2093
P356
P1433
P1476
Functionalised staple linkages for modulating the cellular activity of stapled peptides
@en
P2093
Ashok R. Venkitaraman
Chandra Verma
Christopher J. Brown
David P. Lane
David R. Spring
Laura S. Itzhaki
Luca Laraia
Marko Hyvönen
Niklas Sköld
Pamela J. E. Rowling
P304
P356
10.1039/C4SC00045E
P577
2014-01-01T00:00:00Z