Quantifying the Slightly Deleterious Mutation Model of Molecular Evolution
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Non-silent story on synonymous sites in voltage-gated ion channel genesThe distribution of fitness effects of new deleterious amino acid mutations in humansEstimating the distribution of fitness effects from DNA sequence data: implications for the molecular clockAn integrated view of protein evolutionWeak selection and protein evolutionEvolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primatesEvidence for widespread degradation of gene control regions in hominid genomesGenome-wide acceleration of protein evolution in flies (Diptera).Methods to detect selection on noncoding DNAThe role of robustness in phenotypic adaptation and innovationLong-Term Balancing Selection at the West Nile Virus Resistance Gene, Oas1b, Maintains Transspecific Polymorphisms in the House MouseRecent and ongoing selection in the human genomeShould tissue structure suppress or amplify selection to minimize cancer risk?Reconstructing the phylogenetic history of long-term effective population size and life-history traits using patterns of amino acid replacement in mitochondrial genomes of mammals and birdsThe evolution of intron size in amniotes: a role for powered flight?In with the old, in with the new: the promiscuity of the duplication process engenders diverse pathways for novel gene creationHorizontal gene transfer dynamics and distribution of fitness effects during microbial in silico evolutionEffective population size is positively correlated with levels of adaptive divergence among annual sunflowersWidespread genomic signatures of natural selection in hominid evolutionAccumulation of slightly deleterious mutations in mitochondrial protein-coding genes of large versus small mammalsGenetic diversity, population structure and Wolbachia infection status in a worldwide sample of Drosophila melanogaster and D. simulans populations.A selection index for gene expression evolution and its application to the divergence between humans and chimpanzeesPurifying selection in mitochondria, free-living and obligate intracellular proteobacteria.Understanding the evolutionary fate of finite populations: the dynamics of mutational effects.The role of genetic variation in the causation of mental illness: an evolution-informed framework.Fully Bayesian tests of neutrality using genealogical summary statistics.What can we learn about the distribution of fitness effects of new mutations from DNA sequence data?Properties of human disease genes and the role of genes linked to Mendelian disorders in complex disease aetiology.Shifts in the intensity of purifying selection: an analysis of genome-wide polymorphism data from two closely related yeast species.Gene genealogies strongly distorted by weakly interfering mutations in constant environments.Efficient purging of deleterious mutations in plants with haploid selfing.Lineage-specific differences in the amino acid substitution processEvolutionary analysis of a streamlined lineage of surface ocean Roseobacters.Landscape of standing variation for tandem duplications in Drosophila yakuba and Drosophila simulans.Weak selection revealed by the whole-genome comparison of the X chromosome and autosomes of human and chimpanzeeGenome wide analyses reveal little evidence for adaptive evolution in many plant species.Drosophila duplication hotspots are associated with late-replicating regions of the genomeReduced selective constraint in endosymbionts: elevation in radical amino acid replacements occurs genome-wide.Estimating the distribution of selection coefficients from phylogenetic data using sitewise mutation-selection models.Toward a realistic model of mutations affecting fitness.
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Quantifying the Slightly Deleterious Mutation Model of Molecular Evolution
description
article
@en
im Dezember 2002 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в грудні 2002
@uk
name
Quantifying the Slightly Deleterious Mutation Model of Molecular Evolution
@en
Quantifying the Slightly Deleterious Mutation Model of Molecular Evolution
@nl
type
label
Quantifying the Slightly Deleterious Mutation Model of Molecular Evolution
@en
Quantifying the Slightly Deleterious Mutation Model of Molecular Evolution
@nl
prefLabel
Quantifying the Slightly Deleterious Mutation Model of Molecular Evolution
@en
Quantifying the Slightly Deleterious Mutation Model of Molecular Evolution
@nl
P2093
P2860
P1476
Quantifying the slightly deleterious mutation model of molecular evolution
@en
P2093
Adam Eyre-Walker
Nick G C Smith
Peter D Keightley
P2860
P304
P356
10.1093/OXFORDJOURNALS.MOLBEV.A004039
P577
2002-12-01T00:00:00Z