Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival
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Understanding platelet generation from megakaryocytes: implications for in vitro-derived plateletsMcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistagesSome viral microRNAs were up-regulated in megakaryocytes incubated with immune thrombocytopenia plasma.Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice.The role of apoptosis in megakaryocytes and platelets.Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways.Mitoquinone restores platelet production in irradiation-induced thrombocytopenia.The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling.BCL-2 is dispensable for thrombopoiesis and platelet survivalNovel mechanisms of platelet clearance and thrombopoietin regulation.Regulation of platelet lifespan by apoptosis.Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling.Shear enhances thrombopoiesis and formation of microparticles that induce megakaryocytic differentiation of stem cells.Regulating billions of blood platelets: glycans and beyond.Delving deeper: MCL-1's contributions to normal and cancer biology.Programming cancer cells for high expression levels of Mcl1.Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy.Morphogenesis of the lymphatic vasculature: A focus on new progenitors and cellular mechanisms important for constructing lymphatic vessels.Bcl-2 proteins in development, health, and disease of the hematopoietic system.A link between the driver mutations and dysregulated apoptosis in BCR-ABL1 negative myeloproliferative neoplasms.The lymphatic vasculature: development and role in shaping immunity.Non-apoptotic functions of caspases in myeloid cell differentiation.Low carbohydrate diet prevents Mcl-1-mediated resistance to BH3-mimeticsDysregulation of the intrinsic apoptotic pathway mediates megakaryocytic hyperplasia in myeloproliferative neoplasms.Anti-apoptotic BCL-2 family members in development.Effects of vascular endothelial growth factors and their receptors on megakaryocytes and platelets and related diseases.Megakaryocytic hyperplasia in myeloproliferative neoplasms is driven by disordered proliferative, apoptotic and epigenetic mechanisms.Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice.The Plant Hormone Abscisic Acid Is a Prosurvival Factor in Human and Murine Megakaryocytes.Differential effects of Vav-promoter-driven overexpression of BCLX and BFL1 on lymphocyte survival and B cell lymphomagenesis.Targeting BCL-2 regulated apoptosis in cancer.
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Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival
description
article
@en
im Februar 2012 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в лютому 2012
@uk
name
Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival
@en
Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival
@nl
type
label
Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival
@en
Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival
@nl
prefLabel
Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival
@en
Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival
@nl
P2093
P50
P1433
P1476
Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival
@en
P2093
Chloé James
Emma C Josefsson
Katya J Henley
Marion Lebois
Marlyse A Debrincat
Rachael M Lane
P304
P356
10.1182/BLOOD-2011-12-398834
P407
P50
P577
2012-02-28T00:00:00Z