DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling

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DDK Has a Primary Role in Processing Stalled Replication Forks to Initiate Downstream Checkpoint Signaling

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wetenschappelijk artikel

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наукова стаття, опублікована в жовтні 2018

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DDK Has a Primary Role in Proc ...... ownstream Checkpoint Signaling

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DDK Has a Primary Role in Proc ...... ownstream Checkpoint Signaling

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DDK Has a Primary Role in Proc ...... ownstream Checkpoint Signaling

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DDK Has a Primary Role in Proc ...... ownstream Checkpoint Signaling

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DDK Has a Primary Role in Proc ...... ownstream Checkpoint Signaling

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DDK Has a Primary Role in Proc ...... ownstream Checkpoint Signaling

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P1476

DDK Has a Primary Role in Proc ...... ownstream Checkpoint Signaling

@en

P2093

Flavie Coquel

http://www.w3.org/2001/XMLSchema#string

Jeffrey P MacKeigan

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Michael Weinreich

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Yea-Lih Lin

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P2860

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint.

Discovery of XL413, a potent and selective CDC7 inhibitor

Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects

Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells

The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds

Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway.

The role of the Saccharomyces cerevisiae Cdc7-Dbf4 complex in the replication checkpoint.

A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.

Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress

P304

985-995

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P31

scholarly article

P356

10.1016/J.NEO.2018.08.001

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P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Philippe Pasero

Nanda-Kumar Sasi

P577

2018-10-01T00:00:00Z

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P698

30157471

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P921

cancer research

P932

6111017

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